This paper introduces a holistic framework to assist less industrialized countries in adopting nuclear energy (NE) for peaceful purposes considering the challenges and opportunities this entails. It underscores the pressing need for sustainable and secure energy solutions, proposing NE as a viable option. The study aims to delve into the technical, social, economic, regulatory, and policy aspects of NE's development and its broader applications beyond conventional power generation, such as industrial processes, medical applications, agricultural advancements, and mining activities, explicitly targeting less industrialized regions. Employing a systematic review of existing practices, the paper identifies and examines barriers to NE adoption alongside strategies to mitigate these issues. Findings suggest that NE can play a pivotal role in fostering economic growth and scientific progress, potentially sparking the emergence of new industries within these countries. However, significant obstacles-namely governance, public acceptance, safety, security, development of expertise, and securing financing-pose considerable challenges. The paper concludes that a strategic and well-coordinated deployment of NE is essential for driving socio-economic growth and environmental sustainability in less industrialized countries. It emphasizes the necessity for comprehensive planning and international collaboration to fully unlock NE's potential, advocating for a multifaceted approach to overcome the identified hurdles.