Higher-end science and technology facilitate the human community with a sophisticated life despite it curses by abundant pollution. The alarming demand for sustainability pressurizes the manufacturing sector to ensure sustainable manufacturing. Since Molybdenum di sulfide (MoS2) and avocado oil are known solid and liquid lubricants respectively, hence, it is a worthwhile attempt to implement the bio-based degradable avocado oil enriched with nano Molybdenum di sulfide (nMoS2) particles as a potential machining fluid for CNC-end milling. Different proportions of avocado oil and nMoS2 were used to synthesise four distinct machining fluids to assess the individual impact of avocado oil and nMoS2 particles. The emulsification and sonication were employed to synthesise the fluids. A hybrid Grey Relational Analysis (GRA) coupled with Principal Component Analysis (PCA) was followed to scrutiny the effect of novel machining fluid on machining objectives. The experimental results of physio-chemical properties revealed that avocado-rich 0.5% nMoS2 excels among others. The L16 orthogonal array experiments associated with statistical analysis explored the developed machining fluid (A6W4/0.5) that significantly impacts the machining objectives. The experimental results manifest that nearly 64.87% of surface roughness and 93.3% of tool wear have been reduced during machining in the presence of A6W4/0.5 fluid than A4W6/0.75. The improved performance of the novel machining fluid upholds its potential to replace conventional fluids and ensure green manufacturing.