The use of extended light spectra, including UV-A, green, and far-red, has been scarcely explored in vertical farming. This study evaluated the effects of full spectra under two intensities (90 and 180 mu mol m-2 s-1) on the growth and antioxidant properties of green and purple leaf lettuce. Three light spectra were tested: Blue-White (BW), Red-White (RW), and Red-Blue (RB). Fresh weight (FW), dry weight percentage (DWP), chlorophyll concentration (NDVI), and antioxidant parameters (total phenolic content (TPC), antioxidant capacity by DPPH and FRAP and total flavonoid content (TFC)) were assessed. Spectrum-intensity interactions significantly influenced FW, with RW-180 mu mol m-2 s-1 yielding the highest FW (78.2 g plant-1 in green and 48.5 g plant-1 in purple lettuce). BW-90 mu mol m-2 s-1 maximized DWP in green lettuce, while PAR intensity of 180 mu mol m-2 s-1 favored DWP in purple lettuce. Chlorophyll concentration increased under PAR intensity of 180 mu mol m-2 s-1, and leaf color varied with spectrum, with RW producing lighter leaves. Antioxidant parameters declined over time, but a PAR intensity of 180 mu mol m-2 s-1, particularly under RW, boosted TPC and TFC contents in both lettuce cultivars during early stages (days 0 and 15). Conversely, a lower PAR intensity of 90 mu mol m-2 s-1, mainly under RW, enhanced antioxidant capacity by FRAP at 15 days and by the end of the cycle for both cultivars. Overall, RW-180 mu mol m-2 s-1 interactions promoted the best characteristics in lettuce. Nonetheless, the findings emphasize the significance of fine-tuning both light spectrum and intensity to enhance lettuce growth and quality in vertical farming systems considering the cultivar, time and variable to be evaluated.