Objective: This systematic review evaluates the color-matching ability (Delta E-00 values) and chromatic stability of single-shade chameleon dental resin composites in restorative dentistry. Methods: A comprehensive search of PubMed, Scopus, Web of Science, Embase, and Cochrane Library was conducted following PRISMA guidelines. Studies assessing color adaptation and stability of single-shade composites in vitro, in clinical trials, and in retrospective analyses were included. Results: Seven studies (four in vitro, two clinical trials, one retrospective study) reported Delta E-00 values within clinically acceptable thresholds (< 3.3). Clinical trials showed that single-shade composites (e.g., Omnichroma, Vittra APS Unique) achieved comparable aesthetic outcomes to multi-shade composites over 12-18 months. Factors such as staining agents and cavity depth influenced color stability, with coffee exposure causing the most discoloration. Bleaching procedures induced minimal color shifts. Study heterogeneity limited meta-analysis. Conclusion: Single-shade chameleon resin composites provide reliable color adaptation and stability, streamlining shade selection and reducing clinical time. However, staining susceptibility and restoration depth must be considered for long-term aesthetic success.