Capillary refill time has emerged as a relevant monitoring variable for septic shock resuscitation. It represents skin microcirculation a territory affected by blood flow redistribution during shock states similarly as the hepatosplanchinc region. Monitoring CRT may allow clinicians to assess clinical reperfusion with this universally available and costless variable as supported by strong background epidemiological data and a major RCT. Targeting CRT normalization may be relevant for stopping active resuscitation in a timely fashion and thus avoiding the risk of over-resuscitation. More interestingly, the rapid kinetics of response of CRT to flow increasing maneuvers such as fluid or MAP challenges may be pivotal in determining the status of macro-to microcirculatory coupling at the bedside. The results of the ongoing ANDROMEDASHOCK-2 will define if personalizing septic shock resuscitation with the use of simple clinical tools may improve relevant outcomes in this severe condition. (c) 2024 l'Acade<acute accent>mie nationale de me<acute accent>decine. Published by Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.