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| DOI | 10.7717/PEERJ-CS.2590 | ||||
| Año | 2024 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Alzheimer's disease (AD) is a condition with a complex pathogenesis, sometimes hereditary, characterized by the loss of neurons and synapses, along with the presence of senile plaques and neurofibrillary tangles. Early detection, particularly among individuals at high risk, is critical for effective treatment or prevention, yet remains challenging due to data variability and incompleteness. Most current research relies on single data modalities, potentially limiting comprehensive staging of AD. This study addresses this gap by integrating multimodal data-including clinical and genetic information-using deep learning (DL) models, with a specific focus on random vector functional link (RVFL) networks, to enhance early detection of AD and mild cognitive impairment (MCI). Our findings demonstrate that ensemble deep RVFL (edRVFL) models, when combined with effective data imputation techniques such as Winsorized-mean (Wmean), achieve superior performance in detecting early stages of AD. Notably, the edRVFL model achieved an accuracy of 98.8%, precision of 98.3%, recall of 98.4%, and F1-score of 98.2%, outperforming traditional machine learning models like support vector machines, random forests, and decision trees. This underscores the importance of integrating advanced imputation strategies and deep learning techniques in AD diagnosis.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Henriquez, Pablo A. | - |
Universidad Diego Portales - Chile
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| 2 | Araya, Nicolas | - |
Universidad Diego Portales - Chile
Pontificia Universidad Católica de Chile - Chile |
| Fuente |
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| ANID Fondecyt |
| Chilean National Agency for Research and Development (ANID) |
| Agencia Nacional de Investigación y Desarrollo |
| ANID FONDECYT Iniciacion Grant |
| Agradecimiento |
|---|
| This work was supported by the Chilean National Agency for Research and Development (ANID) through ANID/PIA/ANILLOS ACT210096; ANID FONDECYT Iniciacion Grant 11230396. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| This work was supported by the Chilean National Agency for Research and Development (ANID) through ANID/PIA/ANILLOS ACT210096; ANID FONDECYT Iniciaci\u00F3n Grant 11230396. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |