Introduction: chronic kidney disease involves a gradual and irreversible loss of renal function, impacting nephrons and quality of life due to dialytic treatment on physical, psychological, and independence levels. The objective was to determine the quality of life of users with chronic kidney disease undergoing hemodialysis in Nuble, Chile. Method: a quantitative, descriptive study with 153 users was conducted. The Kidney Disease and Quality of Life – 36 questionnaire was administered, assessing quality of life across four subscales. Results: the majority (59,5 %) were male, with 51,6 % aged over 61. The average quality of life score was 47,7, with notable emphasis on “Perception of physical and mental health” (71,9 %) and “Burden of kidney disease” (77,1 %). Conclusions: the quality of life of users with chronic kidney disease in this study was characterized by an average below 50 %, indicating a generally low evaluation.