The drastic changes caused by the pandemic brought with them psychological disorders, as a result of the measures adopted for its management . University students, in their adaptation, presented difficulties in academic performance and greater university dropout. Therefore, the objective of this study is to evaluate the impact of the COVID-19 pandemic on the frequency of psychological symptoms in undergraduate medical students at the University of Antofagasta. This is a correlational, observational and cross-sectional study with the application of the Goldberg-GHQ-12 sociodemographic and health questionnaires to 85 undergraduate medical students at the University of Antofagasta. In the area of mental health, the overall score was very high (31.7 out of 38), indicating that there is a possibility that the students suffered an emotional disorder that demonstrated a worse state of mental health, with mood being the most affected area. . 31.8% consumed psychoactive substances and 18.8% reported that they had to face conflicts and violence occasionally. In terms of psychological well-being, social functioning and coping, the students in our study obtained results with better mental health status compared to other populations; It is suggested that taking a proactive attitude helped confront the problems associated with the pandemic. However, in the area of mood, they showed worse results than those described worldwide, which reinforces the idea that the university population increases its vulnerability in environmental crises.