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Departamento Gestión de Conocimiento, Monitoreo y Prospección
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Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas
| Indexado |
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| DOI | 10.1016/J.XGEN.2024.100692 | ||||
| Año | 2024 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
Latin Americans are underrepresented in genetic studies, increasing disparities in personalized genomic medicine. Despite available genetic data from thousands of Latin Americans, accessing and navigating the bureaucratic hurdles for consent or access remains challenging. To address this, we introduce the Genetics of Latin American Diversity (GLAD) Project, compiling genome-wide information from 53,738 Latin Americans across 39 studies representing 46 geographical regions. Through GLAD, we identified heterogeneous ancestry composition and recent gene flow across the Americas. Additionally, we developed GLAD-match, a simulated annealing-based algorithm, to match the genetic background of external samples to our database, sharing summary statistics (i.e., allele and haplotype frequencies) without transferring individual-level genotypes. Finally, we demonstrate the potential of GLAD as a critical resource for evaluating statistical genetic software in the presence of admixture. By providing this resource, we promote genomic research in Latin Americans and contribute to the promises of personalized medicine to more people.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Borda, Victor | Hombre |
UNIV MARYLAND - Estados Unidos
University of Maryland School of Medicine - Estados Unidos |
| 2 | Loesch, Douglas P. | - |
UNIV MARYLAND - Estados Unidos
University of Maryland School of Medicine - Estados Unidos |
| 3 | Guo, Bing | - |
University of Maryland School of Medicine - Estados Unidos
|
| 4 | Laboulaye, Roland | - |
UNIV MARYLAND - Estados Unidos
University of Maryland School of Medicine - Estados Unidos |
| 5 | Veliz-Otani, Diego | - |
UNIV MARYLAND - Estados Unidos
University of Maryland School of Medicine - Estados Unidos |
| 6 | French, Jennifer N. | - |
UNIV MARYLAND - Estados Unidos
University of Maryland School of Medicine - Estados Unidos |
| 7 | Leal, Thiago Peixoto | - |
CLEVELAND CLIN - Estados Unidos
Cleveland Clinic Foundation - Estados Unidos |
| 8 | Gogarten, Stephanie M. | Mujer |
UNIV WASHINGTON - Estados Unidos
University of Washington - Estados Unidos |
| 9 | Ikpe, Sunday | - |
UNIV MARYLAND - Estados Unidos
University of Maryland School of Medicine - Estados Unidos |
| 10 | Gouveia, Mateus H. | - |
Natl Human Genome Res Inst - Estados Unidos
National Human Genome Research Institute (NHGRI) - Estados Unidos |
| 11 | Mendes, Marla | - |
Univ Fed Minas Gerais - Brasil
Universidade Federal de Minas Gerais - Brasil |
| 12 | Abecasis, Goncalo R. | - |
UNIV MICHIGAN - Estados Unidos
University of Michigan School of Public Health - Estados Unidos |
| 13 | Alvim, Isabela | - |
Univ Fed Minas Gerais - Brasil
Universidade Federal de Minas Gerais - Brasil |
| 14 | Arboleda-Bustos, Carlos E. | - |
UNIV NACL COLOMBIA - Colombia
Universidad Nacional de Colombia - Colombia |
| 15 | Arboleda, Gonzalo | Hombre |
UNIV NACL COLOMBIA - Colombia
Universidad Nacional de Colombia - Colombia |
| 16 | Arboleda, Humberto | Hombre |
UNIV NACL COLOMBIA - Colombia
Universidad Nacional de Colombia - Colombia |
| 17 | Barreto, Mauricio L. | - |
Univ Fed Bahia - Brasil
Universidade Federal da Bahia - Brasil |
| 18 | Barwick, Lucas | - |
Emmes Co - Estados Unidos
Emmes Company - Estados Unidos |
| 19 | Bezzera, Marcos A. | - |
Univ Fed Pernambuco - Brasil
Universidade Federal de Pernambuco - Brasil |
| 20 | Blangero, J. | Hombre |
Univ Texas Rio Grande Valley - Estados Unidos
University of Texas Rio Grande Valley School of Medicine - Estados Unidos |
| 21 | Borges, Vanderci | - |
Univ Fed Sao Paulo - Brasil
Universidade de São Paulo - Brasil Universidade Federal de São Paulo - Brasil |
| 22 | Caceres, Omar | - |
INST NACL SALUD - Perú
Univ Cient Sur - Perú National Institute of Health, Lima - Perú Universidad Científica del Sur - Perú |
| 23 | Cai, Jianwen | - |
Univ North Carolina - Estados Unidos
UNC Gillings School of Global Public Health - Estados Unidos |
| 24 | Chana-Cuevas, Pedro | - |
Universidad de Santiago de Chile - Chile
|
| 25 | Chen, Zhanghua | - |
Univ Southern Calif - Estados Unidos
Keck School of Medicine of USC - Estados Unidos |
| 26 | Custer, Brian | - |
Vitalant Res Inst - Estados Unidos
Vitalant Research Institute - Estados Unidos |
| 27 | Dean, Michael | Hombre |
Natl Canc Inst - Estados Unidos
National Cancer Institute (NCI) - Estados Unidos |
| 28 | Dinardo, Carla | - |
UNIV SAO PAULO - Brasil
Universidade de São Paulo - Brasil |
| 29 | Domingos, Igor | - |
Univ Fed Pernambuco - Brasil
Universidade Federal de Pernambuco - Brasil |
| 30 | Duggirala, Ravindranath | - |
Univ Texas Rio Grande Valley - Estados Unidos
University of Texas Rio Grande Valley School of Medicine - Estados Unidos |
| 31 | Dieguez, Elena | Mujer |
UNIV REPUBLICA - Uruguay
Universidad de la República - Uruguay |
| 32 | Fernandez, William | Hombre |
Universidad Nacional de Colombia - Colombia
|
| 33 | Ferraz, Henrique B. | - |
Univ Fed Sao Paulo - Brasil
Universidade de São Paulo - Brasil Universidade Federal de São Paulo - Brasil |
| 34 | Gilliland, Frank | - |
Univ Southern Calif - Estados Unidos
Keck School of Medicine of USC - Estados Unidos |
| 35 | Guio, Heinner | - |
INST NACL SALUD - Perú
INBIOMEDIC Res Ctr - Perú Univ Huainuco - Perú National Institute of Health, Lima - Perú INBIOMEDIC Research and Technological Center - Perú Universidad de Huánuco - Perú |
| 36 | Horta, Bernardo | - |
Univ Fed Pelotas - Brasil
Universidade Federal de Pelotas, Faculdade de Medicina - Brasil |
| 37 | Curran, Joanne E. | - |
University of Texas Rio Grande Valley School of Medicine - Estados Unidos
|
| 38 | Johnsen, Jill M. | - |
Bloodworks Northwest Res Inst - Estados Unidos
Bloodworks Northwest Research Institute - Estados Unidos |
| 39 | Kaplan, Robert C. | - |
Albert Einstein Coll Med - Estados Unidos
Fred Hutchinson Canc Ctr - Estados Unidos Albert Einstein College of Medicine - Estados Unidos Fred Hutchinson Cancer Center - Estados Unidos |
| 40 | Kelly, Shannon | - |
Vitalant Res Inst - Estados Unidos
UNIV CALIF SAN FRANCISCO - Estados Unidos Vitalant Research Institute - Estados Unidos UCSF Benioff Children's Hospital Oakland - Estados Unidos University of California, San Francisco - Estados Unidos |
| 41 | Kenny, Eimear E. | - |
Icahn Sch Med Mt Sinai - Estados Unidos
Icahn School of Medicine at Mount Sinai - Estados Unidos |
| 42 | Konkle, Barbara A. | - |
UNIV WASHINGTON - Estados Unidos
University of Washington School of Medicine - Estados Unidos University of Washington - Estados Unidos |
| 43 | Kooperberg, Charles | Hombre |
Fred Hutchinson Canc Ctr - Estados Unidos
Fred Hutchinson Cancer Center - Estados Unidos |
| 44 | Lescano, Andres G. | Hombre |
UNIV REPUBLICA - Uruguay
Universidad de la República - Uruguay |
| 45 | Lima-Costa, M. Fernanda | - |
Fundacao Oswaldo Cruz - Brasil
|
| 46 | Loos, Ruth J. F. | - |
Icahn Sch Med Mt Sinai - Estados Unidos
Icahn School of Medicine at Mount Sinai - Estados Unidos |
| 47 | Manichaikul, Ani | - |
UNIV VIRGINIA - Estados Unidos
University of Maryland School of Medicine - Estados Unidos University of Virginia School of Medicine - Estados Unidos |
| 48 | Meyers, Deborah A. | - |
UNIV ARIZONA - Estados Unidos
The University of Arizona - Estados Unidos |
| 49 | Naslavsky, Michel S. | - |
UNIV SAO PAULO - Brasil
Universidade de São Paulo - Brasil |
| 50 | Nickerson, Deborah A. | - |
UNIV WASHINGTON - Estados Unidos
University of Washington - Estados Unidos |
| 51 | North, Kari E. | - |
Univ North Carolina Chapel Hill - Estados Unidos
UNC Gillings School of Global Public Health - Estados Unidos |
| 52 | Padilla, Carlos | Hombre |
INST NACL SALUD - Perú
National Institute of Health, Lima - Perú |
| 53 | Preuss, Michael | Hombre |
Icahn School of Medicine at Mount Sinai - Estados Unidos
|
| 54 | Raggio, Victor | - |
UNIV REPUBLICA - Uruguay
Universidad de la Republica Facultad de Medicina - Uruguay Universidad de la República - Uruguay |
| 55 | Reiner, Alexander P. | - |
Fred Hutchinson Canc Ctr - Estados Unidos
UNIV WASHINGTON - Estados Unidos University of Washington - Estados Unidos Fred Hutchinson Cancer Center - Estados Unidos |
| 56 | Rich, Stephen S. | - |
University of Maryland School of Medicine - Estados Unidos
University of Virginia School of Medicine - Estados Unidos |
| 57 | Rieder, Carlos R. | - |
Univ Fed Ciencias Saude Porto Alegre - Brasil
Universidade Federal de Ciências da Saúde de Porto Alegre - Brasil |
| 58 | Rienstra, Michiel | Hombre |
Univ Groningen - Países Bajos
Universitair Medisch Centrum Groningen - Países Bajos |
| 59 | Rotter, Jerome I. | - |
Harbor UCLA Med Ctr - Estados Unidos
Harbor-UCLA Medical Center - Estados Unidos |
| 60 | Rundek, Tatjana | - |
UNIV MIAMI - Estados Unidos
University of Miami Leonard M. Miller School of Medicine - Estados Unidos |
| 61 | Sacco, Ralph L. | - |
UNIV MIAMI - Estados Unidos
University of Miami Leonard M. Miller School of Medicine - Estados Unidos |
| 62 | Sanchez, Cesar | - |
National Institute of Health, Lima - Perú
|
| 63 | Sankaran, Vijay G. | - |
Harvard Med Sch - Estados Unidos
Broad Inst MIT & Harvard - Estados Unidos Harvard Medical School - Estados Unidos Broad Institute - Estados Unidos |
| 64 | Santos-Lobato, Bruno Lopes | - |
Univ Fed Para - Brasil
Universidade Federal da Bahia - Brasil Universidade Federal do Pará - Brasil |
| 65 | Schumacher-Schuh, Artur Francisco | - |
Univ Fed Rio Grande do Sul - Brasil
Hosp Clin Porto Alegre - Brasil Universidade Federal do Rio Grande do Sul - Brasil Hospital de Clínicas de Porto Alegre - Brasil |
| 66 | Scliar, Marilia O. | - |
UNIV SAO PAULO - Brasil
Universidade de São Paulo - Brasil |
| 67 | Silverman, Edwin K. | - |
Brigham & Womens Hosp - Estados Unidos
Brigham and Women's Hospital - Estados Unidos |
| 68 | Sofer, Tamar | Mujer |
Harvard Med Sch - Estados Unidos
Harvard Medical School - Estados Unidos |
| 69 | Lasky-Su, Jessica | - |
Brigham & Womens Hosp - Estados Unidos
Brigham and Women's Hospital - Estados Unidos |
| 70 | Tumas, Vitor | - |
UNIV SAO PAULO - Brasil
Universidade de São Paulo - Brasil |
| 71 | Weiss, Scott T. | - |
Brigham & Womens Hosp - Estados Unidos
Brigham and Women's Hospital - Estados Unidos |
| 72 | Mata, Ignacio F. | - |
UNIV MARYLAND - Estados Unidos
University of Maryland School of Medicine - Estados Unidos |
| 73 | Hernandez, Ryan D. | - |
UNIV CALIF SAN FRANCISCO - Estados Unidos
University of California, San Francisco - Estados Unidos UCSF School of Medicine - Estados Unidos California Institute for Quantitative Biosciences - Estados Unidos Department of Bioengineering and Therapeutic Sciences - Estados Unidos |
| 74 | Tarazona-Santos, Eduardo | - |
UNIV PERUANA CAYETANO HEREDIA - Perú
Universidade Federal de Minas Gerais - Brasil Universidad Peruana Cayetano Heredia - Perú |
| 75 | O'Connor, Timothy D. | - |
UNIV MARYLAND - Estados Unidos
University of Maryland School of Medicine - Estados Unidos |
| 76 | Latin Amer Res Consortium Genet Parkinsons Dis LARGE PD | Corporación | |
| 77 | Natl Inst Neurol Disorders and Stroke NINDS Stroke Genetics | Corporación | |
| 78 | Trans-Omics For Precision Med | Corporación |
| Fuente |
|---|
| Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq |
| NIH |
| National Institutes of Health |
| Fundação de Amparo à Pesquisa do Estado de Minas Gerais |
| National Heart, Lung, and Blood Institute |
| National Human Genome Research Institute |
| National Institute of Neurological Disorders and Stroke |
| National Institute on Aging |
| FAPEMIG (Fundacao de Amparo a Pesquisa do Estado de Minas Gerais) |
| Ministério da Saúde |
| National Heart, Lung, and Blood Institute (NHLBI) |
| National Heart, Lung, and Blood Institute of the NIH |
| NIH/NINDS |
| Broad Institute |
| MESA |
| TOPMed Informatics Research Center |
| McDonnell Genome Institute |
| 'National Heart, Lung, and Blood Institute (NHLBI)' |
| Programa Nacional de Genomica e Saude de Precisao-Genomas Brasil from the Brazilian Ministry of Health (CNPq) |
| National Human Genome Research Institute of the NIH |
| Research Training in the Epidemiology of Aging - National Institute on Aging |
| Genetics of Parkinson's Disease |
| NINDS-sponsored Stroke Genetics Network |
| Baylor College of Medicine Human Genome Sequencing Center |
| Research Training in the Epidemiology of Aging |
| Singapore Immunology Network |
| Northwest Genomics Center |
| Agradecimiento |
|---|
| We would like to thank Evangeline ''Eevee'' O'Connor for assistance in providing an acronym that is both accurate and contributes to generally uplifting our research. T.D.O., V.B., R.L., and D.V.-O. were supported by the National Human Genome Research Institute of the NIH under award no. R35HG010692. E.T.-S. was supported by FAPEMIG (Fundacao de Amparo a Pesquisa do Estado de Minas Gerais) RED 00314-16, Programa Nacional de Genomica e Saude de Precisao-Genomas Brasil from the Brazilian Ministry of Health (CNPq Process 403502/2020-9) and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq. R.D.H. is supported by the NIH under award no. R01 GM142112. D.P.L. was supported by the National Heart, Lung, and Blood Institute of the NIH under award no. T32 HL00769825. J.N.F. was supported by Research Training in the Epidemiology of Aging, funded by the National Institute on Aging under award no. T32 AG000262. The Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD) is funded by the NIH/NINDS through award no. R01 NS112499. The NINDS-sponsored Stroke Genetics Network (SiGN) is funded by the NIH/NINDS under award nos. R01 NS105150 and R01 NS100178. The Genome Sequencing for the Trans-Omics in Precision Medicine (TOPMed) program was supported by the National Heart, Lung, and Blood Institute (NHLBI). Genome sequencing for ''NHLBI TOPMed: The Genetic Epidemiology of Asthma in Costa Rica'' (phs000988.v3p1) was performed at Northwest Genomics Center (HHSN268201600032I/3R37HL066289-13S1). Genome sequencing for ''NHLBI TOPMed: San Antonio Family Heart Study (SAFHS)'' (phs001215.v4.p2) was performed at Illumina (3R01HL11332303S1 and R01HL113322). Genome sequencing for ''NHLBI TOPMed: Women's Health Initiative (WHI)'' (phs001237.v3.p1) was performed at Broad Institute Genomics Platform (HHSN268201500014C). Genome sequencing for ''NHLBI TOPMed: Hispanic Community Health Study -Study of Latinos (HCHS/SOL)'' (phs001395.v2.p1) was performed at Baylor College of Medicine Human Genome Sequencing Center (HHSN268201600033I). Genome sequencing for ''NHLBI TOPMed: Multi-Ethnic Study of Atherosclerosis'' (MESA) (phs001416.v2.p1) was performed at Broad Institute Genomics Platform (3U54HG003067-13S1). Genome sequencing for ''NHLBI TOPMed: Severe Asthma Research Program (SARP)'' (phs001446.v2.p1) was performed at New York Genome Center Genomics (3U54HG003067-13S1). Genome sequencing for ''NHLBI TOPMed: Recipient Epidemiology and Donor Evaluation Study-III Brazil Sickle Cell Disease Cohort (REDS-BSCDC)'' (phs001468.v3.p1) was performed at Baylor College of Medicine Human Genome Sequencing Center (HHSN268201600033I/HHSN268201500015C). Genome sequencing for ''NHLBI TOPMed: My Life Our Future (MLOF) Research Repository of Patients with Hemophilia A (Factor VIII Deficiency) or Hemophilia B (Factor IX Deficiency)'' (phs001515.v2.p2) was performed at New York Genome Center Genomics (HHSN268201500016C). Genome sequencing for ''NHLBI TOPMed: Boston-Brazil Sickle Cell Disease (SCD) Cohort'' (phs001599.v1.p1) was performed at Baylor College of Medicine Human Genome Sequencing Center (HHSN268201600033I, HHSN268201500015C, and HHSN268201600033). Genome sequencing for ''NHLBI TOPMed: Children's Health Study (CHS) Integrative Genomics and Environmental Research of Asthma (IGERA)'' (phs001603.v2.p1) was performed at Northwest Genomics Center (HHSN268201600032I). Genome sequencing for ''NHLBI TOPMed: Children's Health Study (CHS) Effects of Air Pollution on the Development of Obesity in Children (Meta-AIR)'' (phs001604.v2. p1) was performed at Northwest Genomics Center (HHSN268201600032I). Genome sequencing for ''NHLBI TOPMed: NHGRI CCDG: The BioMe Biobank at Mount Sinai'' (phs001644.v2.p2) was performed at Baylor College of Medicine Human Genome Sequencing Center (HHSN268201600033I) and the McDonnell Genome Institute (HHSN268201600037I). Genome sequencing for ''NHLBI TOPMed: Lung Tissue Research Consortium (LTRC)'' (phs001662.v2.p1) was performed at Broad Institute Genomics Platform (HHSN268201600034I). Genome sequencing for ''NHLBI TOPMed: Childhood Asthma Management Program (CAMP)'' (phs0017265.v2.p1) was performed at Northwest Genomics Center (HHSN268201600032I). Core support, including centralized genomic read mapping and genotype calling, along with variant quality metrics and filtering, were provided by the TOPMed Informatics Research Center (3R01HL-117626-02S1; contract HHSN268201800002I). Core support, including phenotype harmonization, data management, sample-identity QC, and general program coordination, were provided by the TOPMed Data Coordinating Center (R01HL-120393 and U01HL-120393; contract HHSN268201800001I). We gratefully acknowledge the studies and participants who provided biological samples and data for TOPMed. The full study-specific acknowledgments are included in Data S1. |
| We would like to thank Evangeline \u201CEevee\u201D O'Connor for assistance in providing an acronym that is both accurate and contributes to generally uplifting our research. T.D.O., V.B., R.L., and D.V.-O. were supported by the National Human Genome Research Institute of the NIH under award no. R35HG010692. E.T.-S. was supported by FAPEMIG (Funda\u00E7\u00E3o de Amparo \u00E0 Pesquisa do Estado de Minas Gerais) RED 00314-16, Programa Nacional de Gen\u00F4mica e Sa\u00FAde de Precis\u00E3o \u2013 Genomas Brasil from the Brazilian Ministry of Health (CNPq Process 403502/2020-9) and Conselho Nacional de Desenvolvimento Cient\u00EDfico e Tecnol\u00F3gico - CNPq. R.D.H. is supported by the NIH under award no. R01 GM142112. D.P.L. was supported by the National Heart, Lung, and Blood Institute of the NIH under award no. T32 HL007698-25. J.N.F. was supported by Research Training in the Epidemiology of Aging, funded by the National Institute on Aging under award no. T32 AG000262. The Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD) is funded by the NIH/NINDS through award no. R01 NS112499. The NINDS-sponsored Stroke Genetics Network (SiGN) is funded by the NIH/NINDS under award nos. R01 NS105150 and R01 NS100178. The Genome Sequencing for the Trans-Omics in Precision Medicine (TOPMed) program was supported by the National Heart, Lung, and Blood Institute (NHLBI). Genome sequencing for \u201CNHLBI TOPMed: The Genetic Epidemiology of Asthma in Costa Rica\u201D (phs000988.v3p1) was performed at Northwest Genomics Center (HHSN268201600032I/3R37HL066289-13S1). Genome sequencing for \u201CNHLBI TOPMed: San Antonio Family Heart Study (SAFHS)\u201D (phs001215.v4.p2) was performed at Illumina (3R01HL113323-03S1 and R01HL113322). Genome sequencing for \u201CNHLBI TOPMed: Women's Health Initiative (WHI)\u201D (phs001237.v3.p1) was performed at Broad Institute Genomics Platform (HHSN268201500014C). Genome sequencing for \u201CNHLBI TOPMed: Hispanic Community Health Study - Study of Latinos (HCHS/SOL)\u201D (phs001395.v2.p1) was performed at Baylor College of Medicine Human Genome Sequencing Center (HHSN268201600033I). Genome sequencing for \u201CNHLBI TOPMed: Multi-Ethnic Study of Atherosclerosis\u201D (MESA) (phs001416.v2.p1) was performed at Broad Institute Genomics Platform (3U54HG003067-13S1). Genome sequencing for \u201CNHLBI TOPMed: Severe Asthma Research Program (SARP)\u201D (phs001446.v2.p1) was performed at New York Genome Center Genomics (3U54HG003067-13S1). Genome sequencing for \u201CNHLBI TOPMed: Recipient Epidemiology and Donor Evaluation Study-III Brazil Sickle Cell Disease Cohort (REDS-BSCDC)\u201D (phs001468.v3.p1) was performed at Baylor College of Medicine Human Genome Sequencing Center (HHSN268201600033I/HHSN268201500015C). Genome sequencing for \u201CNHLBI TOPMed: My Life Our Future (MLOF) Research Repository of Patients with Hemophilia A (Factor VIII Deficiency) or Hemophilia B (Factor IX Deficiency)\u201D (phs001515.v2.p2) was performed at New York Genome Center Genomics (HHSN268201500016C). Genome sequencing for \u201CNHLBI TOPMed: Boston-Brazil Sickle Cell Disease (SCD) Cohort\u201D (phs001599.v1.p1) was performed at Baylor College of Medicine Human Genome Sequencing Center (HHSN268201600033I, HHSN268201500015C, and HHSN268201600033). Genome sequencing for \u201CNHLBI TOPMed: Children's Health Study (CHS) Integrative Genomics and Environmental Research of Asthma (IGERA)\u201D (phs001603.v2.p1) was performed at Northwest Genomics Center (HHSN268201600032I). Genome sequencing for \u201CNHLBI TOPMed: Children's Health Study (CHS) Effects of Air Pollution on the Development of Obesity in Children (Meta-AIR)\u201D (phs001604.v2.p1) was performed at Northwest Genomics Center (HHSN268201600032I). Genome sequencing for \u201CNHLBI TOPMed: NHGRI CCDG: The BioMe Biobank at Mount Sinai\u201D (phs001644.v2.p2) was performed at Baylor College of Medicine Human Genome Sequencing Center (HHSN268201600033I) and the McDonnell Genome Institute (HHSN268201600037I). Genome sequencing for \u201CNHLBI TOPMed: Lung Tissue Research Consortium (LTRC)\u201D (phs001662.v2.p1) was performed at Broad Institute Genomics Platform (HHSN268201600034I). Genome sequencing for \u201CNHLBI TOPMed: Childhood Asthma Management Program (CAMP)\u201D (phs0017265.v2.p1) was performed at Northwest Genomics Center (HHSN268201600032I). Core support, including centralized genomic read mapping and genotype calling, along with variant quality metrics and filtering, were provided by the TOPMed Informatics Research Center (3R01HL-117626-02S1; contract HHSN268201800002I). Core support, including phenotype harmonization, data management, sample-identity QC, and general program coordination, were provided by the TOPMed Data Coordinating Center (R01HL-120393 and U01HL-120393; contract HHSN268201800001I). We gratefully acknowledge the studies and participants who provided biological samples and data for TOPMed. The full study-specific acknowledgments are included in Data S1. |
