Introduction: Knowing the RF and EF in people with ASD reported by families is relevant for the diagnosis and the generation of a person-centered support plan. Objective: Relate the RF and EF reported by families at the time of a diagnostic evaluation of ASD. Method: Cross-sectional and quantitative study of 305 responses from adults responsible for people evaluated in the city of Vina del Mar (Chile). 43 RF responses and the means of EF obtained in the test (BRIEF) were correlated and the differences in frequencies according to gender and age were analyzed. Results: Significant relationship (p<0.05) in male gender in RF of late onset of word use and lack of consistency in eye contact. In children under 6 years of age, there was the presence of tantrums, self- harm and stereotyped movements and in EF of change and emotional control in those over 6 years of age. Language and communication RF were associated with alterations in Inhibition (r=0.165; p<0.01), Mental flexibility (r=0.125; p<0.05) and Planning (r=0.130; p<0.05) controlled by gender, while when controlling by age, these RF were associated with alterations in Mental flexibility (r=0.175; p<0.01) and Working memory (r=0.145; p<0.05). Conclusion: In the presence of RF and EF alterations there are gender and age differences that must be considered when performing a diagnostic evaluation for ASD and at the time of screening in the at- risk population. The association between RF and EF allows anticipating support in early care in children under 6 years of age and in the female gender and installing programs that promote the quality of life of the people evaluated throughout the life cycle.