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Liver X receptor unlinks intestinal regeneration and tumorigenesis
| Indexado |
|
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| DOI | 10.1038/S41586-024-08247-6 | ||||
| Año | 2024 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
Liver X receptor drives epithelial Areg-mediated intestinal regeneration, while preventing tumour growth through adaptive immune responses.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Das, Srustidhar | - |
Karolinska Inst - Suecia
Univ Hosp - Suecia Karolinska Institutet - Suecia Center of Molecular Medicine - Suecia |
| 2 | Parigi, S. Martina | - |
Karolinska Inst - Suecia
Univ Hosp - Suecia Rockefeller Univ - Estados Unidos Karolinska Institutet - Suecia Center of Molecular Medicine - Suecia Rockefeller University - Estados Unidos |
| 3 | Luo, Xinxin | - |
Karolinska Inst - Suecia
Univ Hosp - Suecia Karolinska Institutet - Suecia Center of Molecular Medicine - Suecia |
| 4 | Fransson, Jennifer | - |
Karolinska Inst - Suecia
Univ Hosp - Suecia Karolinska Institutet - Suecia Center of Molecular Medicine - Suecia |
| 5 | Kern, Bianca C. | - |
Karolinska Inst - Suecia
Univ Hosp - Suecia Karolinska Institutet - Suecia Center of Molecular Medicine - Suecia |
| 6 | Okhovat, Ali | - |
Karolinska Inst - Suecia
Univ Hosp - Suecia Karolinska Institutet - Suecia Center of Molecular Medicine - Suecia |
| 7 | Diaz, Oscar E. | - |
Karolinska Inst - Suecia
Univ Hosp - Suecia Karolinska Institutet - Suecia Center of Molecular Medicine - Suecia |
| 8 | Sorini, Chiara | - |
Karolinska Inst - Suecia
Univ Hosp - Suecia Karolinska Institutet - Suecia Center of Molecular Medicine - Suecia |
| 9 | Czarnewski, Paulo | - |
Karolinska Inst - Suecia
Univ Hosp - Suecia Stockholm Univ - Suecia Karolinska Institutet - Suecia Center of Molecular Medicine - Suecia Science for Life Laboratory - Suecia |
| 10 | Webb, Anna T. | - |
Karolinska Inst - Suecia
Karolinska Institutet - Suecia |
| 11 | Morales, Rodrigo A. | - |
Karolinska Inst - Suecia
Univ Hosp - Suecia Karolinska Institutet - Suecia Center of Molecular Medicine - Suecia |
| 12 | Lebon, Sacha | - |
Weizmann Inst Sci - Israel
Weizmann Institute of Science Israel - Israel |
| 13 | Monasterio, Gustavo | - |
Karolinska Inst - Suecia
Univ Hosp - Suecia Karolinska Institutet - Suecia Center of Molecular Medicine - Suecia |
| 14 | Castillo, Francisca | - |
Karolinska Inst - Suecia
Univ Hosp - Suecia Karolinska Institutet - Suecia Center of Molecular Medicine - Suecia |
| 15 | Tripathi, Kumar P. | - |
Karolinska Inst - Suecia
Univ Hosp - Suecia Karolinska Institutet - Suecia Center of Molecular Medicine - Suecia |
| 16 | He, Ning | - |
Karolinska Inst - Suecia
Univ Hosp - Suecia Karolinska Institutet - Suecia Center of Molecular Medicine - Suecia |
| 17 | Pelczar, Penelope | - |
Univ Klinikum Hamburg Eppendorf - Alemania
Universitätsklinikum Hamburg-Eppendorf - Alemania |
| 18 | Schaltenberg, Nicola | - |
Univ Klinikum Hamburg Eppendorf - Alemania
Universitätsklinikum Hamburg-Eppendorf - Alemania |
| 19 | De la Fuente, Marjorie | - |
Universidad Finis Terrae - Chile
Universidad de Chile - Chile |
| 20 | Lopez-Kostner, Francisco | - |
Universidad de Los Andes, Chile - Chile
Universidad De Los Andes, Merida - Venezuela |
| 21 | Nylen, Susanne | - |
Karolinska Inst - Suecia
Karolinska Institutet - Suecia |
| 22 | Larsen, Hjalte List | - |
Univ Copenhagen - Dinamarca
Københavns Universitet - Dinamarca |
| 23 | Kuiper, Raoul | - |
Norwegian Vet Inst - Noruega
Karolinska Inst - Suecia Veterinærinstituttet - Noruega Karolinska Institutet - Suecia |
| 24 | Antonson, Per | - |
Karolinska Inst - Suecia
Karolinska Institutet - Suecia |
| 25 | Hermoso, Marcela A. | - |
Universidad de Chile - Chile
|
| 26 | Huber, Samuel | - |
Univ Klinikum Hamburg Eppendorf - Alemania
Universitätsklinikum Hamburg-Eppendorf - Alemania |
| 27 | Biton, Moshe | - |
Weizmann Inst Sci - Israel
Weizmann Institute of Science Israel - Israel |
| 28 | Scharaw, Sandra | - |
Karolinska Inst - Suecia
Max Planck Inst Mol Cell Biol & Genet - Alemania Karolinska Institutet - Suecia Max Planck Institute of Molecular Cell Biology and Genetics - Alemania |
| 29 | Gustafsson, Jan-Ake | - |
Karolinska Inst - Suecia
UNIV HOUSTON - Estados Unidos |
| 29 | Gustafsson, Jan Åke | - |
Karolinska Institutet - Suecia
College of Natural Sciences and Mathematics - Estados Unidos UNIV HOUSTON - Estados Unidos |
| 30 | Katajisto, Pekka | - |
Karolinska Inst - Suecia
Univ Helsinki - Finlandia Karolinska Institutet - Suecia Institute of Biotechnology - Finlandia |
| 31 | Villablanca, Eduardo J. | - |
Karolinska Inst - Suecia
Univ Hosp - Suecia Karolinska Univ Hosp - Suecia Karolinska Institutet - Suecia Center of Molecular Medicine - Suecia Karolinska Universitetssjukhuset - Suecia |
| Fuente |
|---|
| China Scholarship Council |
| European Union |
| European Research Council |
| Swedish Research Council |
| European Research Council (ERC) |
| Vetenskapsradet |
| Novo Nordisk Foundation |
| Horizon 2020 Framework Programme |
| Cancerfonden |
| European Federation of Pharmaceutical Industries and Associations |
| Kungliga Tekniska Högskolan |
| Ontario Institute for Cancer Research |
| Novo Nordisk Fonden |
| FORMAS |
| Swedish Research Council VR |
| Swedish National Infrastructure for Computing (SNIC) |
| Svenska Forskningsradet Formas |
| Ake Wiberg Stiftelse |
| Innovative Medicines Initiative |
| EFPIA |
| Silicon Valley Community Foundation |
| Chan Zuckerberg Initiative |
| Innovative Medicines Initiative 2 Joint Undertaking (JU) |
| SciLifeLab |
| Chan Zuckerberg Initiative DAF |
| Diamond Light Source Limited |
| Kungliga Tekniska Hoegskolan |
| BioImage Informatics Facility, a unit of the National Bioinformatics Infrastructure Sweden NBIS |
| Ake Weibergs Stiftelse |
| National Bioinformatics Infrastructure Sweden (NBIS) |
| Wallenberg Academy Fellow |
| National Microscopy Infrastructure NMI |
| Royal Institution for the Advancement of Learning McGill University |
| Royal Institution |
| BioImage Informatics Facility |
| Diamond Light Source |
| Novo Nordisk Foundation Centre for Stem Cell Medicine |
| Agradecimiento |
|---|
| We thank the Villablanca laboratory members for discussions; N. Nedelsky for editorial assistance; S. Inampudi and M. Shaik for their help with experiments; the staff at the FENO facility for tissue processing. The computations/data handling was enabled by resources provided by the Swedish National Infrastructure for Computing (SNIC), under project number SNIC 2017/7-445 and partially funded by the Swedish Research Council through grant agreement no. 2018-05973. We also thank the staff at the National Bioinformatics Infrastructure Sweden (NBIS) long-term support. The analysis pipeline for salivary glands has been made possible in part by BioImage Informatics Facility, a unit of the National Bioinformatics Infrastructure Sweden NBIS, with funding from SciLifeLab, National Microscopy Infrastructure NMI (VR-RFI 2019-00217) and Chan Zuckerberg Initiative DAF (DAF2021-225261, https://doi.org/10.37921/644085ggkbos, an advised fund of Silicon Valley Community Foundation, https://doi.org/10.13039/100014989). The Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW) are supported by a Novo Nordisk Foundation grant number NNF21CC0073729. This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875510. The JU receives support from the European Union's Horizon 2020 research and innovation programme and EFPIA and Ontario Institute for Cancer Research, Royal Institution for the Advancement of Learning McGill University, Kungliga Tekniska Hoegskolan, Diamond Light Source Limited. This communication reflects the views of the authors and the JU is not liable for any use that may be made of the information contained herein. X.L. was supported by grants from China Scholarship Council (nr. 201907930012). S.D. was supported by Cancerfonden (CAN 2016/1206), ake Weibergs Stiftelse (M21-0074, M22-0048, M23-0179); and E.J.V. by grants from the Swedish Research Council VR (K2015-68X-22765-01-6, 2018-02533 and 2021-01277), FORMAS (FR-2016/0005 and 2022-01066), Cancerfonden (19 0395 Pj and 22 2060 Pj), European Research Council (ERC) Synergy Grant 101118531, and Wallenberg Academy Fellow (WAF) program (2019.0315 and 2024.0135). |
| We thank the Villablanca laboratory members for discussions; N. Nedelsky for editorial assistance; S. Inampudi and M. Shaik for their help with experiments; the staff at the FENO facility for tissue processing. The computations/data handling was enabled by resources provided by the Swedish National Infrastructure for Computing (SNIC), under project number SNIC 2017/7-445 and partially funded by the Swedish Research Council through grant agreement no. 2018-05973. We also thank the staff at the National Bioinformatics Infrastructure Sweden (NBIS) long-term support. The analysis pipeline for salivary glands has been made possible in part by BioImage Informatics Facility, a unit of the National Bioinformatics Infrastructure Sweden NBIS, with funding from SciLifeLab, National Microscopy Infrastructure NMI (VR-RFI 2019-00217) and Chan Zuckerberg Initiative DAF (DAF2021-225261, https://doi.org/10.37921/644085ggkbos, an advised fund of Silicon Valley Community Foundation, https://doi.org/10.13039/100014989). The Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW) are supported by a Novo Nordisk Foundation grant number NNF21CC0073729. This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875510. The JU receives support from the European Union\u2019s Horizon 2020 research and innovation programme and EFPIA and Ontario Institute for Cancer Research, Royal Institution for the Advancement of Learning McGill University, Kungliga Tekniska Hoegskolan, Diamond Light Source Limited. This communication reflects the views of the authors and the JU is not liable for any use that may be made of the information contained herein. X.L. was supported by grants from China Scholarship Council (nr. 201907930012). S.D. was supported by Cancerfonden (CAN 2016/1206), \u00C5ke Weibergs Stiftelse (M21-0074, M22-0048, M23-0179); and E.J.V. by grants from the Swedish Research Council VR (K2015-68X-22765-01-6, 2018-02533 and 2021-01277), FORMAS (FR-2016/0005 and 2022-01066), Cancerfonden (19 0395 Pj and 22 2060 Pj), European Research Council (ERC) Synergy Grant 101118531, and Wallenberg Academy Fellow (WAF) program (2019.0315 and 2024.0135). |
