Neuroeducation allows us to understand the learning process from a neuroscience standpoint. This knowledge makes it easier for academics to understand the importance of emotions and executive functions in learning. Based on this neuroscientific foundation, this article addresses the main characteristics of the brain processes that occur in active methodologies. This allows the reader to assess their importance and understand why active methodologies should be considered first choice methodologies for achieving deep learning. In particular, the clinical simulation strategy is reviewed, aligned with the active methodologies used in the training of health professionals. In conclusion, the importance of neuroeducation is highlighted for an effective and conscious implementation of clinical simulation, not only from the execution technique, but also from the neuroscientific foundation, which allows optimal benefit on the part of the students in the area of health.