The use of 3D printing has spread in various areas, including medical education, from its support for the study of human anatomy to the training of surgical techniques given the benefits of " Hands-On-Learning" learning. The objective of the present research is to clarify the impact of3D printing on the learning of medical students, as well as to determine in which areas of their curriculum it has been implemented. To do this, a systematic review of the available literature was carried out. The databases used were PubMed, CINAHL, PsycINFO, ERIC, Web of Science and SCOPUS, using the following 4 concepts: "3D Printing" AND "Medical Education" AND "Outcome of Education" AND "Higher Education". Publications in English and Spanish were considered. 3,326 studies were identified up to October 2023 (705 duplicates). Using the PRISMA2020 protocol and the COVIDENCE software, four authors reviewed the results and selected those that met inclusion and exclusion criteria. 2,561 studies were excluded, with 60 studies identified for full-text reading. Of these, 34 met the proposed inclusion criteria, and were ultimately reviewed and synthesized by the authors. Among the findings, there is a trend to investigate thee ducational role of 3D printing in areas of anatomy, various pathologies, radiology, and simulation. When comparing 3D printing with 2D models, better post-intervention scores were found in the 3D group. Regarding cadaveric models, 3D printing again shows better results in anatomical learning, although there were also studies that did not show significant differences, however, none reported inferiority of 3D printing as a teaching tool. Finally, a limited number of studies were found on its impact on long-term learning. 3D printing is shown to have a positive impact on learning in various areas of medical training.