Depression is a very important mental health issue in Chile, traditionally associated with stigmatization and viewed from an individual perspective. Messages disseminated through mass media and social media could contribute to shaping and perpetuating these biased views about the disease, hindering access to timely diagnosis and treatment for those affected. This study aims to characterize the conversation on Twitter about depression in Chile in 2021 from a framing perspective. A quantitative content analysis was conducted on a random sample of 1,063 tweets to determine the presence of stigma and anti-stigma frames, as well as the attribution of individual or social responsibility. An intercoder reliability test was carried out before coding the entire sample. It was found that the most prevalent frame was that of social factors associated with depression, and that the distribution of frames of stigma, anti-stigma, and individual factors was balanced. Examination of the coexistence of frames in the discussion revealed that posts referring to the suicidal stereotype associated with depression were more likely to emphasize individual causes. It is suggested that contextual factors in Chile in 2021, such as the social upheaval of2019 and the COVID-19 pandemic, may explain the emphasis on social factors when discussing depression.