The management of proteinuria in patients with lupus nephritis represents a challenge for the specialist. Recently, Calcineurin Inhibitors have been positioned as an effective alternative in these patients, but their use is not widespread in our country. We report the experience of three centers in this regard. Methods: a review of lupus nephritis patients treated with Tacrolimus from 3 centers in southern Chile. Results: Data from 10 patients with Lupus nephritis were obtained. All of them had significant proteinuria after the traditional induction scheme. In most of them, there was a significant decrease in proteinuria without deterioration of creatinine at 12 months after treatment with Tacrolimus alone or in combination with Mycophenolate. Conclusions: Tacrolimus alone or in combination with Mycophenolate is a safe and effective alternative in the management of Lupus nephritis-associated proteinuria.