We present the implementation of a novel economic model predictive control (E-MPC) strategy for froth flotation, the largest tonnage mineral separation process. A previously calibrated and validated dynamic model incorporating froth physics was used, which overcomes the limitations of previous simplified models reported in the literature. The EMPC's optimal control problem was solved using full discretization with orthogonal collocation over finite elements, employing automatic differentiation via CasADi. This approach was applied in a 30-litre laboratory-scale flotation cell, significantly improving mineral recovery from 9% to 29% under feed flowrate disturbances while maintaining a minimum concentrate grade of 20%.