Two-dimensional covalent organic frameworks (2D COFs) are an emerging class of crystalline porous materials formed through covalent bonds between organic building blocks. COFs uniquely combine a large surface area, an excellent stability, numerous abundant active sites, and tunable functionalities, thus making them highly attractive for numerous applications. Especially, their abundant active sites and weak interlayer interaction make these materials promising candidates for tribological research. Recently, notable attention has been paid to COFs as lubricant additives due to their excellent tribological performance. Our review aims at critically summarizing the state-of-art developments of 2D COFs in tribology. We discuss their structural and functional design principles, as well as synthetic strategies with a special focus on tribology. The generation of COF thin films is also assessed in detail, which can alleviate their most challenging drawbacks for this application. Subsequently, we analyze the existing state-of-the-art regarding the usage of COFs as lubricant additives, self-lubrication composite coatings, and solid lubricants at the nanoscale. Finally, critical challenges and future trends of 2D COFs in tribology are outlined to initiate and boost new research activities in this exciting field.