BACKGROUND Clinical and ultrasound experience has revealed that after soft tissue injections of the lateral cheek, the filler may displace from the zygoma to the caudal temporal area.OBJECTIVE To obtain more data to provide insight into product distribution when soft tissue fillers are injected in the zygomatic region.METHODS Two hundred patients were examined with facial ultrasound imaging of the zygomatic and temporal region.Inclusion criteria were simply a positive response on the screening questionnaire as to whether or not they had filler injections placed in their lateral cheek.Control injections were also performed to the zygomatic regions of a body donor and in 10 patients ultrasound-guided.RESULTS A correlation was found between the layers in which filler was detected on the zygoma and where it was ultimately found in the temples.Four different redistribution patterns were observed: (1) migration of filler within the superficial muscular aponeurotic system (SMAS) on the zygoma into the superficial temporal fascia.Migration of filler from the lateral suborbicularis oculi fat to (2) the deep interfacial plane of the temple or (3) to the superficial temporal fat pad; (4) migration from the supraperiosteal layer of the zygoma to the superficial temporal fat pad.Body donor and patients: filler deposits injected on the zygoma were witnessed to shift during injection into the caudal part of the temple.CONCLUSION Soft tissue filler aliquots may be redistributed into the temples after injections of the lateral side of the zygomatic arch.The displacement follows a distinct pattern depending on the initial layer of injection.