The radiological study of the breast has been evolving technologically, from analog mammography, through indirect digital mammography, to full-field digital mammography (FFDM). One of the latest advances has been digital breast tomosynthesis (DBT), a technique that generates an almost three-dimensional mammogram that reduces the overlap of fibroglandular tissue and has shown an increase in the detection of cancers, which is why it is becoming the standard in screening and diagnosis programs worldwide. Since the food and drug administration initially approved its use together with FFDM, an increase in the radiation received by the patient was generated, although always below the established limit of 3 mGy per exposure. To solve this problem, synthesized mammography (s2D) was developed, in which a mammogram is obtained from the DBT, eliminating the need to perform a FFDM and reducing radiation by approximately half. The objective of this review article is to review the technical characteristics of s2D and show the published evidence, answering frequently asked questions.