This study investigates the resilience of informally-constructed light-frame timber houses in Puerto Rico, a region where households with limited resources face significant risks from climate hazards, notably hurricanes. This study conducts a component-based, performance-based wind engineering assessment of informally-constructed house typologies, defined based on extensive fieldwork, under both existing and projected future climate conditions. Key findings highlight the effectiveness of certain mitigation strategies, such as reinforcing roof-to-wall connections, in significantly reducing the probability of failure. Fully-mitigated cases, which involve applying mitigation measures to the roof envelope, roof-to-wall connections, and shear walls, exhibited annual probabilities of failure that are much closer to, but do not necessarily meet, the threshold targeted by American building standards (i.e., ASCE 7). The results also show a dramatic increase in probability of failure of these houses projected by the adopted climate change model scenarios, driven by the increased frequency and intensity of hurricanes in Puerto Rico. Results from feedback from those working in the informal construction sector also identify challenges hindering the effective implementation of mitigation measures in Puerto Rican communities, including a lack of knowledge about how to implement the mitigation strategies and barriers related to real and perceived costs. Taken together these results underscore the urgent need for changes in building practices and revising building standards and suggesting potentially feasible mitigation strategies to improve those practices.