We investigate the Gauss-Bonnet dark energy model and its deformed version on Horava-Lifshitz cosmology, which belongs to the class of cosmologies obtained from the so-called projectable version of Horava-Lifshitz gravity. In particular, we investigate the bulk/boundary interaction in this scenario through the Q function, which we interpret as a measure of the energy transference between the bulk and the spacetime boundary. Then we discuss whether the thermal equilibrium will be stable or not, once it is reached, and the validity of the generalized second law. We show that the Q function can exhibit sign changes along the cosmic evolution and the Universe reaches the thermal equilibrium as a transient phenomenon.