The discussion regarding the relationship between housing and care within the general field of housing studies has generated a broadening of the field in many ways. One of such is the reciprocal relationship between the numerous forms of housing transformation and care, particularly for low-income communities in the Global South. We suggest that the main drive to transform housing incrementally is care. Following the work of Power and Mee (2019), we consider housing as an infrastructure of care and therefore, the incremental transformation of housing as part of a set of practices, which produce a sociomaterial assemblage that is constitutive of care. Under these practices, not only does housing pattern care relations, but care relations also pattern housing and therefore housing transformations. This relational way of seeing housing and care is increasingly relevant in the implementation of housing transformation programmes and policies, as this would impact incremental housing design, programme, operation, funding, and implementations, particularly in the context of an increasing incorporation of multiple alternatives of housing transformation and improvement in public housing in the Global South. We show this through ethnographic work on housing transformation for care purposes in the city of Alto Hospicio, Chile.