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| DOI | 10.1016/J.TJNUT.2024.06.011 | ||||
| Año | 2024 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Background: In low/middle-income countries, most nutritional assessments use the latest weights, without reference to growth trajectory. Objectives: This study explores whether velocity, in addition to the latest weight, improves the prediction of wasting, stunting, or mortality in the fi rst 2 years of life. Methods: We analyzed a combined data set with weight and height data collected monthly in the fi rst year of 3447 children from Pakistan, Malawi, and South Africa, with height and survival recorded till 24 m. The main exposures were weight-for-age z-score (WAZ) at the end of each 2-m period and weight velocity-for-age z-score (WVZ2) 2 ) across that period. The outcomes were wasting, stunting, or all-cause mortality in the next 1-2 - 2 mo. As a sensitivity analysis, we also used WVZ over 6 mo (WVZ6), 6 ), with matching WAZ. Cox proportional hazard models with repeated growth measures were used to study the association between exposures and mortality. Mixed Poisson models were used for stunting and wasting. Results: Children who were already stunted or wasted were most likely to remain so. Higher WVZ2 2 was associated with a lower risk of subsequent stunting (risk ratio [RR]: 0.95; 95% confidence fi dence interval [CI]: 0.93, 0.96), but added minimal prediction (difference in AUC = 0.004) compared with a model including only WAZ. Similarly, lower WVZ2 2 was associated with wasting (RR: 0.74; 95% CI 0.72, 0.76) but the prediction was only marginally greater than for WAZ (difference in AUC = 0.015). Compared with WAZ, WVZ6 6 was less predictive for both wasting and stunting. Low WVZ6 6 (but not WVZ2) 2 ) was associated with increased mortality (hazard ratios: 0.75, 95% CI: 0.67, 0.85), but added only marginal prediction to a model including WAZ alone (difference in C = 0.015). Conclusions: The key anthropometric determinant of impending wasting, stunting, and mortality appears to be how far below the normal range the child's ' s weight is, rather than how they reached that position.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Wright, Charlotte M. | - |
Univ Glasgow - Reino Unido
School of Medicine, Dentistry & Nursing - Reino Unido University of Glasgow - Reino Unido |
| 2 | Petermann-Rocha, Fanny | Mujer |
Universidad Diego Portales - Chile
Facultad de Medicina - Chile |
| 3 | Bland, Ruth | - |
Univ Glasgow - Reino Unido
School of Medicine, Dentistry & Nursing - Reino Unido University of Glasgow - Reino Unido |
| 4 | Ashorn, Per | Hombre |
Tampere Univ - Finlandia
Tampere Univ Hosp - Finlandia University Hospital of Tampere - Finlandia |
| 5 | Zaman, Shakila | - |
Univ Hlth Sci - Pakistán
University of Health Sciences Lahore - Pakistán |
| 6 | Ho, Frederick K. | Hombre |
Univ Glasgow - Reino Unido
University of Glasgow - Reino Unido |
| Fuente |
|---|
| Wellcome Trust |
| World Health Organization |
| Tampereen Yliopisto |
| Wellcome Trust UK |
| Swedish Agency for Research Cooperation with Developing Countries |
| Research Council of Finland |
| Foundations of Mannerheim League for Child Welfare |
| King Edward Medical College, Lahore, Pakistan |
| Swedish Agency for Research Cooperation with Devel-oping Countries (SAREC) |
| University of Tampere |
| Emil Aaltonen Foundation, Foundation for Pediatric Research |
| Research Foundations of Mannerheim League for Child Welfare |
| Medical Research Fund of Tampere University Hospital |
| King Edward Medical College |
| Agradecimiento |
|---|
| This analysis received no specific funding. The individual cohorts were funded from a wide range of sources: Lungwena Child Survival Study: Academy of Finland, Emil Aaltonen Foundation, Foundation for Pediatric Research, Medical Research Fund of Tampere University Hospital, the Research Foundations of Mannerheim League for Child Welfare, and the University of Tampere. Africa Center Vertical Transmission Study: Wellcome Trust UK 063009/Z/00/2. Lahore longitudinal study: Swedish Agency for Research Cooperation with Developing Countries (SAREC) and King Edward Medical College, Lahore, Pakistan.r Foundations of Mannerheim League for Child Welfare, and the University of Tampere. Africa Center Vertical Transmission Study: Wellcome Trust UK 063009/Z/00/2. Lahore longitudinal study: Swedish Agency for Research Cooperation with Devel-oping Countries (SAREC) and King Edward Medical College, Lahore, Pakistan. |
| The 1 possible exception for this is in the assessment of children with moderate or severe acute malnutrition (as indicated by wasting in this study), where the recent growth pattern substantially improved the prediction of persistence or recovery. This may lend support to the practice in many nutrition clinics of monitoring weight gain over time, not just AW, although this is not recommended by WHO [4].This analysis received no specific funding. The individual cohorts were funded from a wide range of sources: Lungwena Child Survival Study: Academy of Finland, Emil Aaltonen Foundation, Foundation for Pediatric Research, Medical Research Fund of Tampere University Hospital, the Research Foundations of Mannerheim League for Child Welfare, and the University of Tampere. Africa Center Vertical Transmission Study: Wellcome Trust UK 063009/Z/00/2. Lahore longitudinal study: Swedish Agency for Research Cooperation with Developing Countries (SAREC) and King Edward Medical College, Lahore, Pakistan. |