In this study, we explore the impact of the galactic interaction/mergers on the central oxygen abundance. We analyse 234 star-forming galaxies included in the Calar Alto Legacy Integral Field Area survey with integrated molecular gas observations from the Atacama Pathfinder EXperiment millimeter telescope and the CARMA interferometer. This database has the most optical integral field spectroscopy data with CO data for yet, with integrated measurements within similar to 1 R-eff. Our sample includes 125 isolated galaxies (control sample) and 109 galaxies in different merging stages. We find that despite whether the merging galaxies show an increase or decrease in their molecular gas fraction, the oxygen abundance does not vary significantly, in comparison to our control sample. Therefore, the enhancement and suppression of oxygen abundance are similar in both isolated galaxies and interacting/merging galaxies. On the contrary, regardless of the merger stage (including isolated sample), galaxies that present an increase in their specific star formation rate present a metallicity dilution. We suggest that both internal and external events affect the chemical composition of merging galaxies.