Disability among indigenous peoples has aroused growing interest in Latin America in recent years. However, the theoretical approach to this field is not univocal. This article aims to discuss the different ways of approaching the understanding of disability in indigenous peoples, understanding that this link can occur in different ways according to the epistemological positioning that sustains the relationship between cultures. It is also recognized that these approaches have consequences both in the academy and in the territories. This reflection will develop seven ways of approaching and suggesting a path, not necessarily linear, but progressive, towards critical interculturality as a research and activist approach in the field of disability among indigenous peoples.