Objective: to establish the relationship between the level of family communica-tion and self-efficacy in patients with Type 2 Diabetes Mellitus attending a primary health center. Methodology: Cross-sectional analytical study. A sample of 238 pa-tients with T2DM was obtained and administered the FACES IV Family Communi-cation Scale and the Diabetes Self-Efficacy Scale. Results: 75.6% identified a "very high" level of family communication significantly related to "support from rela-tives" (p=0.001). Perceived self-efficacy had an overall score of 8.2 with a highly significant correlation between level of communication and self-efficacy items (p-value < 0.05). The highest self-efficacy scores were concentrated in "very high" levels of family communication. Conclusion: High family communication can posi-tively impact the patient’s self-perception and empowerment in the management of their T2DM.