Due to the potential hazard of deepwater oil exploration, the Brazilian industry has an ever-increasing concern for reliability during hydrocarbon production. A major source of concern is mechanical failure in devices, such as safety valves, which can fail without warning, putting both the operation and the environment at risk. A possible reason for malfunction and failure could be the permanent occurrence of vibrations induced by internal two-phase flow during the extraction of fluids from the well. An experimental campaign is proposed to better understand these phenomena. Twenty two-phase flow conditions were tested, with superficial velocities ranging from 0.1 m/s to 2.0 m/s for water, and 0.33 m/s to 7.47 m/s for compressed air. The experiments were carried out in a restricted pipe and a pipe without any restriction to evaluate and compare the vibrations produced by two-phase flow (2-FIV). Three accelerometers positioned downstream of the restriction were used to collect vibrational amplitude spectral density data, 2-D acceleration magnitudes, and RMS values of acceleration. Among the main findings are the roles played by the gas volumetric fraction and the mixture velocity, which strongly influence the vibrational amplitude of both tubes, and the observation that the gas phase is the main responsible for vibrational amplitudes at low frequencies, while the liquid phase acts mainly at high frequencies. Furthermore, the flow pattern is also considered a key feature in determining the vibration level, as 20- and 12-fold increments have been observed for the same volumetric fraction when comparing elongated bubbles and severe slug patterns. Finally, it was demonstrated that the presence of an internal restriction strongly influences the structural response.