An important issue in interconnected microgrids (MGs) is the realization of balance between the generation side and the demand side. Imbalanced generation and load demands lead to security, power quality, and reliability issues. The load frequency control (LFC) is accountable for regulating MG frequency against generation/load disturbances. This paper proposed an optimized fractional order (FO) LFC scheme with cascaded outer and inner control loops. The proposed controller is based on a cascaded one plus tilt derivative (1+TD) in the outer loop and an FO tilt integrator-derivative with a filter (FOTIDF) in the inner loop, forming the cascaded (1+TD/FOTIDF) controller. The proposed 1+TD/FOTIDF achieves better disturbance rejection compared with traditional LFC methods. The proposed 1+TD/FOTIDF scheme is optimally designed using a modified version of the liver cancer optimization algorithm (MLCA). In this paper, a new modified liver cancer optimization algorithm (MLCA) is proposed to overcome the shortcomings of the standard Liver cancer optimization algorithm (LCA), which contains the early convergence to local optima and the debility of its exploration process. The proposed MLCA is based on three improvement mechanisms, including chaotic mutation (CM), quasi-oppositional based learning (QOBL), and the fitness distance balance (FDB). The proposed MLCA method simultaneously adjusts and selects the best 1+TD/FOTIDF parameters to achieve the best control performance of MGs. Obtained results are compared to other designed FOTID, TI/FOTID, and TD/FOTID controllers. Moreover, the contribution of electric vehicles and the high penetration of renewables are considered with power system parameter uncertainty to test the stability of the proposed 1+TD/FOTIDF LFC technique. The obtained results under different possible load/generation disturbance scenarios confirm a superior response and improved performance of the proposed 1+TD/FOTIDF and the proposed MLCA-based optimized LFC controller.