Infrastructure systems are known to be interdependent. Interdependencies among infrastructure systems are often revealed during disruptive events, such as natural disasters. Healthcare infrastructure plays a fundamental role in society after the occurrence of disasters facilitating the response and recovery of communities. This study aims to explore the role of interdependencies in the management of healthcare infrastructure in response to natural disasters such as earthquakes. The authors carried out 15 semi-structured interviews during 2022 and 2023 with stakeholders involved in managing healthcare infrastructure in Chile that were qualitatively analyzed. Our results show that protocols exist to manage healthcare infrastructure during disasters; although the interdependencies between healthcare infrastructure and other urban infrastructure systems (e.g., water infrastructure) are recognized, existing protocols have given limited attention to them. Our results provide healthcare infrastructure agencies with insights to respond to future natural disasters understanding the importance of interdependencies with multiple infrastructure systems.