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Structural and molecular basis of choline uptake into the brain by FLVCR2
| Indexado |
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| DOI | 10.1038/S41586-024-07326-Y | ||||
| Año | 2024 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
FLVCR2 is expressed in the blood-brain barrier of mouse and human, and is the major mediator of choline uptake into the brain.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Cater, Rosemary J. | - |
Columbia Univ - Estados Unidos
UNIV QUEENSLAND - Australia Columbia University - Estados Unidos The University of Queensland - Australia |
| 2 | Mukherjee, Dibyanti | - |
UNIV CALIF SAN FRANCISCO - Estados Unidos
UCSF School of Medicine - Estados Unidos |
| 3 | Gil-Iturbe, Eva | - |
Columbia Univ - Estados Unidos
Columbia University Irving Medical Center - Estados Unidos Columbia University - Estados Unidos |
| 4 | Erramilli, Satchal K. | - |
UNIV CHICAGO - Estados Unidos
The University of Chicago - Estados Unidos |
| 5 | Chen, Ting | - |
Columbia Univ - Estados Unidos
Columbia University - Estados Unidos |
| 6 | Koo, Katie | - |
UNIV CALIF SAN FRANCISCO - Estados Unidos
UCSF School of Medicine - Estados Unidos |
| 7 | SANTANDER-GREZ, NICOLAS GUILLERMO | Hombre |
Universidad de O`Higgins - Chile
Universidad de O’Higgins - Chile |
| 8 | Reckers, Andrew | - |
Columbia Univ - Estados Unidos
Columbia University - Estados Unidos |
| 9 | Kloss, Brian | - |
Columbia Univ - Estados Unidos
Columbia University - Estados Unidos |
| 10 | Gawda, Tomasz | - |
UNIV CHICAGO - Estados Unidos
The University of Chicago - Estados Unidos |
| 11 | Choy, Brendon C. | - |
Columbia Univ - Estados Unidos
Columbia University - Estados Unidos |
| 12 | Zhang, Zhening | - |
Columbia Univ - Estados Unidos
Columbia University - Estados Unidos |
| 13 | Katewa, Aditya | - |
UNIV CALIF SAN FRANCISCO - Estados Unidos
UCSF School of Medicine - Estados Unidos |
| 14 | Larpthaveesarp, Amara | - |
UNIV CALIF SAN FRANCISCO - Estados Unidos
UCSF School of Medicine - Estados Unidos |
| 15 | Huang, Eric J. | - |
UNIV CALIF SAN FRANCISCO - Estados Unidos
San Francisco VA Med Ctr - Estados Unidos UCSF School of Medicine - Estados Unidos San Francisco VA Health Care System - Estados Unidos |
| 16 | Mooney, Scott W. J. | - |
Burke Neurol Inst - Estados Unidos
Burke Neurological Institute - Estados Unidos |
| 17 | Clarke, Oliver B. | - |
Columbia Univ - Estados Unidos
Columbia University - Estados Unidos Columbia University Irving Medical Center - Estados Unidos |
| 18 | Yee, Sook Wah | - |
UNIV CALIF SAN FRANCISCO - Estados Unidos
Department of Bioengineering and Therapeutic Sciences - Estados Unidos |
| 19 | Giacomini, Kathleen M. | - |
UNIV CALIF SAN FRANCISCO - Estados Unidos
Department of Bioengineering and Therapeutic Sciences - Estados Unidos |
| 20 | Kossiakoff, Anthony A. | - |
UNIV CHICAGO - Estados Unidos
The University of Chicago - Estados Unidos |
| 21 | Quick, Matthias | - |
Columbia Univ - Estados Unidos
New York State Psychiat Inst & Hosp - Estados Unidos Columbia University - Estados Unidos Columbia University Irving Medical Center - Estados Unidos New York State Psychiatric Institute - Estados Unidos |
| 22 | Arnold, Thomas | - |
UNIV CALIF SAN FRANCISCO - Estados Unidos
UCSF School of Medicine - Estados Unidos |
| 23 | Mancia, Filippo | - |
Columbia Univ - Estados Unidos
Columbia University - Estados Unidos |
| Fuente |
|---|
| National Institutes of Health |
| Australian Research Council |
| National Institutes of Health (NIH) |
| Australian Research Council Discovery Early Career Researcher Award |
| NIGMS |
| National Institute of General Medical Sciences |
| Center for Membrane Protein Production and Analysis (COMPPa; NIH) |
| NIH K99 Fellowship |
| Agradecimiento |
|---|
| The authors thank members of the Mancia and Arnold laboratories and the Columbia Cryo-EM facility for assistance; and F. F. Gonzalez and R. Pennington for help with in vivo radioactive uptake assays. This work was supported by National Institutes of Health (NIH) grants (R21 NS129105-01 to T.A., F.M. and R.J.C.). R.J.C. has received support through an NIH K99 Fellowship (HL166866-01) and an Australian Research Council Discovery Early Career Researcher Award (DE230101536). The contribution of F.M. is supported by NIGMS grant R35GM132120. Some of the work was performed at the Center for Membrane Protein Production and Analysis (COMPPa; NIH P41 GM116799 to W. A. Hendrickson), previously located at the New York Structural Biology Center. |
| The authors thank members of the Mancia and Arnold laboratories and the Columbia Cryo-EM facility for assistance; and F. F. Gonzalez and R. Pennington for help with in vivo radioactive uptake assays. This work was supported by National Institutes of Health (NIH) grants (R21 NS129105-01 to T.A., F.M. and R.J.C.). R.J.C. has received support through an NIH K99 Fellowship (HL166866-01) and an Australian Research Council Discovery Early Career Researcher Award (DE230101536). The contribution of F.M. is supported by NIGMS grant R35GM132120. Some of the work was performed at the Center for Membrane Protein Production and Analysis (COMPP\u00C5; NIH P41 GM116799 to W. A. Hendrickson), previously located at the New York Structural Biology Center. |
