We studied a multisequal soil succession (MSS) just south of Torres del Paine National Park (51 degrees S), at the presentday core of the Southern Westerly Winds (SWW). The Rio Serrano Section comprises paleosol horizons with associated intervening loess and sandy loess beds formed during the Holocene. Our record suggests strong and stable aeolian activity between -9.3 -7.2 ka followed by a decline with centennial-scale variations until -5 ka. A strengthening commenced at -5 ka and culminated in a maximum between -2.2 -0.5 ka with millennial-scale variations. Subsequent weakening of aeolian activity between -0.5 and 0 ka was coeval with the deposition of a -40 cm-thick paleosol, after which aeolian activity increased abruptly and reached an unprecedented maximum starting in the mid-20th century. The inferred wind intensity variations from our data bear partial agreement with competing hypotheses of SWW evolution, which postulate minimum SWW influence in SW Patagonia during the early Holocene and maximum influence during the Late Holocene, or vice versa. When analyzed through the lens of vegetation physiognomy/distribution and associated hydrological balance inferences from neighboring sites, our results suggest a primary control by precipitation and wind speeds associated to SWW strength at regional scale, modulated by the position of the forest/steppe ecotone east of the austral Andes. Human activities during the mid-20th century (deforestation, fire -regime shifts, livestock grazing, land use changes) caused an unprecedented increase in aeolian activity through decreased vegetation cover that increased sediment availability for aeolian transport, marking a striking difference with the magnitude of natural processes before the Anthropocene. Our results highlight the importance of climate change and natural/human-driven changes in vegetation cover for deciphering wind intensity histories, particularly in the transition from humid to semiarid environments along the eastern slope of the southern Patagonian Andes.