Background: The role of Platelet -rich Plasma injections as a complementary therapy, together with other minimally invasive procedures, has been analyzed previously, however, there are no articles that evaluate the effects of intra-articular infiltration in the Temporomandibular Joint by itself. The aim of this article is to evaluate the effectiveness of intra-articular infiltration with Platelet -rich Plasma, as a single procedure, to both reduce pain and improve clinical parameters in painful joint disorders. Material and Methods: A systematic search was performed using the terms "Temporomandibular Joint Disorders" and "Platelet -rich plasma" in May 2021. Only the Clinical Trials found in the Pubmed/Medline, Embase, Cochrane Library/Cochrane CENTRAL, Google Scholar, and LILACS databases were selected. Results: Only four articles were selected for full -text review. Statistically significant differences were found in pain reduction Platelet -rich Plasma -based interventions with respect to preoperative measurements up to six months. Only two studies found significant intergroup differences favoring Platelet -rich Plasma over other interventions. In relation to maximum mouth opening, three studies reported an increase compared to the preoperative measurements. Conclusions: Platelet -rich Plasma might potentially be effective in reducing pain levels and improving clinical parameters such as interincisal distance. However, studies with better methodological quality, larger sample sizes, and lower risk of bias are required to assess the real value of this intervention in the management of painful joint disorders.