The inappropriate use of antibiotics has favored the adaptation of bacteria resistant to these drugs and is a growing problem in the 21st century. It may affect not only the health of humans but also domestic and wild animals. In this study, we investigated the risk factors and the presence of one type of antibacterial resistance present in the feces of domestic animals and free-living birds in the State of Piau & iacute;, Brazil. A total of 59 samples of the 387 (15.2%) analyzed showed bacterial resistance. Resistant bacteria were found in free-living animals that had never been treated with any medication and in domestic animals raised for subsistence. We hypothesize that the lack of access to veterinary care and information regarding antimicrobial therapy, along with access to antimicrobials without medical prescription, favors the inadequate use of antimicrobials in Piau & iacute; and, thus, contamination of the environment. We recommend an educational outreach platform and the development of public health policies that support the responsible use of antimicrobials in Piau & iacute; and other Brazilian states. The use, misuse, and overuse of antimicrobials is one of the main public health threats of the 21st century. We investigated the risk factor of the presence of extended-spectrum, cephalosporin-resistant Enterobacterales in feces of non-domestic and domestic birds and other domestic animals in Piau & iacute; State, northeast Brazil. We collected a total of 387 cloacal and rectal swab samples of free-living birds, domestic birds, and domestic mammals in five municipalities: Amarante, & Aacute;gua Branca, Lagoa Alegre, Parna & iacute;ba, and Teresina. A total of 59/387 (15.2%) of these samples harbored extended spectrum beta-lactamase (ESBL)-producing Enterobacterales. Using the MALDI-TOF technique, we identified fifty-seven samples as Escherichia coli and two samples as Klebsiella pneumoniae. Teresina and Parna & iacute;ba had the highest prevalence of animals with resistant bacteria (32.1% and 27.1%, respectively) and highest exposure risk factor (OR of 16.06 and 8.58, respectively, and p < 0.001 for all). Multidrug-resistant, ESBL-producing Enterobacterales were observed in 72.8% of the samples (43/59). For the free-living birds, the positive samples belonged to a great kiskadee (Pitangus sulphuratus) and a semipalmated sandpiper (Calidris pusilla) in migratory and resident species, respectively. For domestic animals, the swine samples showed the highest prevalence of antimicrobial resistance. The lack of access to veterinary care and information regarding antimicrobial therapy, along with the easy access to antimicrobials without medical prescription, favors the inadequate use of antimicrobials in Piau & iacute;.