Dataciencia

Colección SciELO Chile

Enhancing precision targeting of ovarian cancer tumor cells in vivo through extracellular vesicle engineering

Indexado

WoS	WOS:001240339500001
Scopus	SCOPUS_ID:85195578865

DOI

10.1002/IJC.35055

Año

2024

Tipo

artículo de investigación

Citas Totales

Autores Afiliación Chile

Instituciones Chile

% Participación
Internacional

Autores
Afiliación Extranjera

Instituciones
Extranjeras

Abstract

Extracellular vesicles (EVs) are promising therapeutic tools for cancer, owing to qualities such as immunogenicity and low toxicity. Enhancing the accumulation of EVs in specific cells and tissues, however, requires improved targeting capabilities. In this study, EVs were modified with ephrin-B2 to explore the effects on targeting and the potential use of EVs specifically against ovarian cancer. Targeting the ephrin-B4 receptor on ovarian cancer cells significantly improved EV uptake by ovarian cancer cells, both in vitro and in vivo. The engineered EVs maintained their characteristic properties while also exhibiting high targeting efficacy, demonstrating the potential of EVs in cancer therapeutics. image

Revista

Revista	ISSN
International Journal Of Cancer	0020-7136

Métricas Externas

PlumX	Altmetric	Dimensions

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Disciplinas de Investigación

WOS
Oncology

Scopus
Sin Disciplinas

SciELO
Sin Disciplinas

Muestra la distribución de disciplinas para esta publicación.

Publicaciones WoS (Ediciones: ISSHP, ISTP, AHCI, SSCI, SCI), Scopus, SciELO Chile.

Colaboración Institucional

Muestra la distribución de colaboración, tanto nacional como extranjera, generada en esta publicación.

Autores - Afiliación

Ord.	Autor	Género	Institución - País
1	Alharbi, Mona	Mujer	UNIV QUEENSLAND - Australia King Saud Univ - Arabia Saudí UQ Centre for Clinical Research - Australia College of Sciences - Arabia Saudí The University of Queensland - Australia
2	Lai, Andrew	Hombre	UNIV QUEENSLAND - Australia UQ Centre for Clinical Research - Australia The University of Queensland - Australia
3	Godbole, Nihar	-	UNIV QUEENSLAND - Australia UQ Centre for Clinical Research - Australia The University of Queensland - Australia
4	Guanzon, Dominic	Hombre	UNIV QUEENSLAND - Australia UQ Centre for Clinical Research - Australia The University of Queensland - Australia
5	Nair, Soumyalekshmi	-	UNIV QUEENSLAND - Australia UQ Centre for Clinical Research - Australia The University of Queensland - Australia
6	ZUNIGA-ARBALTI, FELIPE ANDRES	Hombre	Universidad de Concepción - Chile
7	Quinn, Alexander	-	UNIV QUEENSLAND - Australia UQ Centre for Clinical Research - Australia The University of Queensland - Australia
8	Yang, Mengliu	-	UNIV QUEENSLAND - Australia The University of Queensland - Australia
9	Wu, Sherry Y.	-	UNIV QUEENSLAND - Australia The University of Queensland - Australia
10	SALOMON-GALLO, CARLOS FRANCISCO	Hombre	UNIV QUEENSLAND - Australia UQ Centre for Clinical Research - Australia The University of Queensland - Australia

Muestra la afiliación y género (detectado) para los co-autores de la publicación.

Financiamiento

Fuente
National Health and Medical Research Council
Lions Medical Research Foundation
Ovarian Cancer Research Foundation
Medical Research Future Fund
The Medical Research Future Fund
Donald & Joan Wilson Foundation Ltd
University of Queensland, as part of the Wiley - The University of Queensland agreement via the Council of Australian University Librarians

Muestra la fuente de financiamiento declarada en la publicación.

Agradecimientos

Agradecimiento
The authors would like to Thank Dr Shayna Sharma and Dr Priyakshi Kalita de Croft from the Translational Extracellular Vesicles in Obstetrics and Gynae-Oncology Group at The University of Queensland for their editorial assistance with this manuscript. The graphical abstract and schematic representations in the figures were created entirely or partially using BioRender (). Open access publishing facilitated by The University of Queensland, as part of the Wiley - The University of Queensland agreement via the Council of Australian University Librarians.
This project received funding from the Lion Medical Research Foundation (2015001964), The Medical Research Future Fund (MRF1199984 and GA187319), National Health and Medical Research Council (NHMRC 1195451), The Donald & Joan Wilson Foundation Ltd (2020000323), and Ovarian Cancer Research Foundation (OCRF, 2018001167).

Agradecimiento

The authors would like to Thank Dr Shayna Sharma and Dr Priyakshi Kalita de Croft from the Translational Extracellular Vesicles in Obstetrics and Gynae-Oncology Group at The University of Queensland for their editorial assistance with this manuscript. The graphical abstract and schematic representations in the figures were created entirely or partially using BioRender (). Open access publishing facilitated by The University of Queensland, as part of the Wiley - The University of Queensland agreement via the Council of Australian University Librarians.

This project received funding from the Lion Medical Research Foundation (2015001964), The Medical Research Future Fund (MRF1199984 and GA187319), National Health and Medical Research Council (NHMRC 1195451), The Donald & Joan Wilson Foundation Ltd (2020000323), and Ovarian Cancer Research Foundation (OCRF, 2018001167).