From Nov. 2019 to May 2020, the red supergiant star Betelgeuse experienced an unprecedented drop of brightness in the visible domain called the Great Dimming event (GDE). Large atmospheric dust clouds and large photospheric convective features are suspected to be responsible for it. To better understand the dimming event, we used mid-infrared long-baseline spectro-interferometric measurements of Betelgeuse taken with the Very Large Telescope Interferometer/Multi AperTure mid-Infrared SpectroScopic Experiment (VLTI/MATISSE) instrument before (Dec. 2018), during (Feb. 2020), and after (Dec. 2020) the GDE. We present data in the 3.98-4.15 μm range to cover SiO spectral features molecules as well as adjacent continuum. We have employed geometrical models, image reconstruction, as well as radiative transfer models to monitor the spatial distribution of SiO over the stellar surface. We find a strongly inhomogeneous spatial distribution of SiO that appears to be looking very different between our observing epochs, indicative of a vigorous activity in the stellar atmosphere. The contrast of our images is small in the pseudo-continuum for all epochs, implying that our MATISSE observations support both cold spot and dust cloud model.