Pain Interventionism is dedicated to the practice of “minimally invasive” interventions to relieve pain in cases where the use of medications and non-pharmacological measures are not useful. Chronic pain is a common clinical condition that affects a significant portion of the oncology population. The objective of this review is to show the different interventional therapy alternatives that exist for these patients where pharmacological treatment is not enough to manage their pain. These techniques have proven to be an excellent alternative in this population; however, they should always be considered as a part of the interdisciplinary management of the oncological patient.