The present article explores the evolution of the models used in the medical field, from the biomedical model to the model offered by the framework of 4E Cognition. Additionally, the diagnosis and treatment of illness through the biomedical focus is critiqued due to its reductionist view of the complexity of the health-illness continuum and the human experience. The 4E Cognition model is proposed as a possibility for the practical application of the biopsychosocial model-be it that one of the principle critiques of this model is the difficulty of applicability-given so that the development of concrete interventions from an integrative perspective in the medical sciences are permitted. This article explores the application of the 4E Cognition model in the field of psychiatry and psychology, highlighting the potential role of Mobile Brain-Body Imaging (MoBI) technology for the diagnosis and treatment of diverse neuropsychiatric diagnoses from an integrative perspective that considers physiological, social, psychological, environmental, and structural elements. Finally, possible future directions in terms of research and the applicability of the development of interventions and treatments that are implementing these technologies are explored.