There is a growing awareness that trade affects women and men differently based on their position in the economy, and that it also affects women's empowerment and well-being. Although countries in South America have traditionally imported provisions of trade agreements from developed countries, they have also demonstrated their ability to innovate and design gender-sensible trade regulations. Mainstreaming gender elements into economic and trade policies is crucial for women's empowerment and will have a positive effect on both women's and the region's social and economic development. While some trade agreements have incorporated gender references in their preambles and in provisions relating to cooperation, the very first standalone trade and gender chapter was incorporated in the Chile-Uruguay Free Trade Agreement (FTA). This was followed by other South American countries such as Argentina, Brazil, and Ecuador, that have also incorporated this kind of chapter in their FTAs. Through a review of gender provisions in South American bilateral trade agreements and in the region's main integration processes (Pacific Alliance and Mercosur), this chapter will demonstrate how South America has advanced gender-sensitive trade policymaking which has expanded to other regions.