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Sleep Disorders Associated With Alzheimer's Disease: A Perspective
Indexado
WoS WOS:000433597400001
Scopus SCOPUS_ID:85047869142
DOI 10.3389/FNINS.2018.00330
Año 2018
Tipo revisión

Citas Totales

Autores Afiliación Chile

Instituciones Chile

% Participación
Internacional

Autores
Afiliación Extranjera

Instituciones
Extranjeras


Abstract



Sleep disturbances, as well as sleep-wake rhythm disturbances, are typical symptoms of Alzheimer's disease (AD) that may precede the other clinical signs of this neurodegenerative disease. Here, we describe clinical features of sleep disorders in AD and the relation between sleep disorders and both cognitive impairment and poor prognosis of the disease. There are difficulties of the diagnosis of sleep disorders based on sleep questionnaires, polysomnography or actigraphy in the AD patients. Typical disturbances of the neurophysiological sleep architecture in the course of the AD include deep sleep and paradoxical sleep deprivation. Among sleep disorders occurring in patients with AD, the most frequent disorders are sleep breathing disorders and restless legs syndrome. Sleep disorders may influence circadian fluctuations of the concentrations of amyloid-beta in the interstitial brain fluid and in the cerebrovascular fluid related to the glymphatic brain system and production of the amyloid-beta. There is accumulating evidence suggesting that disordered sleep contributes to cognitive decline and the development of AD pathology. In this mini-review, we highlight and discuss the association between sleep disorders and AD.

Revista



Revista ISSN
Frontiers In Neuroscience 1662-4548

Métricas Externas



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Disciplinas de Investigación



WOS
Sin Disciplinas
Scopus
Neuroscience (All)
SciELO
Sin Disciplinas

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Publicaciones WoS (Ediciones: ISSHP, ISTP, AHCI, SSCI, SCI), Scopus, SciELO Chile.

Colaboración Institucional



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Autores - Afiliación



Ord. Autor Género Institución - País
1 Brzecka, Anna Mujer Wroclaw Med Univ - Polonia
Wroclaw Medical University - Polonia
2 Leszek, Jerzy Hombre Wroclaw Med Univ - Polonia
Wroclaw Medical University - Polonia
3 Ashraf, Ghulam Md Hombre King Abdulaziz Univ - Arabia Saudí
King Abdulaziz University - Arabia Saudí
4 Ejma, Maria Mujer Wroclaw Med Univ - Polonia
Wroclaw Medical University - Polonia
5 AVILA-RODRIGUEZ, MARCO FIDEL Hombre Univ Tolima - Colombia
Universidad del Tolima - Colombia
6 Yarla, Nagendra S. - Gandhi Inst Technol & Management Univ - India
Gandhi Institute of Technology and Management, Visakhapatnam - India
GITAM University - India
7 Tarasov, Vadim V. Hombre Sechenov First Moscow State Med Univ - Rusia
Sechenov First Moscow State Medical University - Rusia
8 Chubarev, Vladimir N. Hombre Sechenov First Moscow State Med Univ - Rusia
Sechenov First Moscow State Medical University - Rusia
9 Samsonova, Anna Mujer Russian Acad Sci - Rusia
Institute of Physiologically Active Compounds of the Russian Academy of Science - Rusia
10 Barreto, George Hombre Pontificia Univ Javeriana - Colombia
Universidad Autónoma de Chile - Chile
Pontificia Universidad Javeriana - Colombia
11 Aliev, Gjumrakch - Russian Acad Sci - Rusia
GALLY Int Biomed Res & Consulting LLC - Estados Unidos
Univ Atlanta - Estados Unidos
Institute of Physiologically Active Compounds of the Russian Academy of Science - Rusia
GALLY International Biomedical Research Consulting LLC - Estados Unidos
University of Atlanta - Estados Unidos

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Financiamiento



Fuente
RSF
IPAC

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Agradecimientos



Agradecimiento
This research was supported in part by RSF project #14-23-00160P and the scientific projects of IPAC (topics 48.8. and 48.9). Authors' also very grateful for the animal facilities were provided by Center for preclinical trials of IPAC RAS.

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