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| DOI | 10.3389/FNINS.2018.00330 | ||||
| Año | 2018 | ||||
| Tipo | revisión |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Sleep disturbances, as well as sleep-wake rhythm disturbances, are typical symptoms of Alzheimer's disease (AD) that may precede the other clinical signs of this neurodegenerative disease. Here, we describe clinical features of sleep disorders in AD and the relation between sleep disorders and both cognitive impairment and poor prognosis of the disease. There are difficulties of the diagnosis of sleep disorders based on sleep questionnaires, polysomnography or actigraphy in the AD patients. Typical disturbances of the neurophysiological sleep architecture in the course of the AD include deep sleep and paradoxical sleep deprivation. Among sleep disorders occurring in patients with AD, the most frequent disorders are sleep breathing disorders and restless legs syndrome. Sleep disorders may influence circadian fluctuations of the concentrations of amyloid-beta in the interstitial brain fluid and in the cerebrovascular fluid related to the glymphatic brain system and production of the amyloid-beta. There is accumulating evidence suggesting that disordered sleep contributes to cognitive decline and the development of AD pathology. In this mini-review, we highlight and discuss the association between sleep disorders and AD.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Brzecka, Anna | Mujer |
Wroclaw Med Univ - Polonia
Wroclaw Medical University - Polonia |
| 2 | Leszek, Jerzy | Hombre |
Wroclaw Med Univ - Polonia
Wroclaw Medical University - Polonia |
| 3 | Ashraf, Ghulam Md | Hombre |
King Abdulaziz Univ - Arabia Saudí
King Abdulaziz University - Arabia Saudí |
| 4 | Ejma, Maria | Mujer |
Wroclaw Med Univ - Polonia
Wroclaw Medical University - Polonia |
| 5 | AVILA-RODRIGUEZ, MARCO FIDEL | Hombre |
Univ Tolima - Colombia
Universidad del Tolima - Colombia |
| 6 | Yarla, Nagendra S. | - |
Gandhi Inst Technol & Management Univ - India
Gandhi Institute of Technology and Management, Visakhapatnam - India GITAM University - India |
| 7 | Tarasov, Vadim V. | Hombre |
Sechenov First Moscow State Med Univ - Rusia
Sechenov First Moscow State Medical University - Rusia |
| 8 | Chubarev, Vladimir N. | Hombre |
Sechenov First Moscow State Med Univ - Rusia
Sechenov First Moscow State Medical University - Rusia |
| 9 | Samsonova, Anna | Mujer |
Russian Acad Sci - Rusia
Institute of Physiologically Active Compounds of the Russian Academy of Science - Rusia |
| 10 | Barreto, George | Hombre |
Pontificia Univ Javeriana - Colombia
Universidad Autónoma de Chile - Chile Pontificia Universidad Javeriana - Colombia |
| 11 | Aliev, Gjumrakch | - |
Russian Acad Sci - Rusia
GALLY Int Biomed Res & Consulting LLC - Estados Unidos Univ Atlanta - Estados Unidos Institute of Physiologically Active Compounds of the Russian Academy of Science - Rusia GALLY International Biomedical Research Consulting LLC - Estados Unidos University of Atlanta - Estados Unidos |