Purpose - The heterogeneous character of Industry 4.0 opens opportunities for studies to understand the difficulties and challenges found in the transformation process of manufacturers. This article aims to present a critical analysis of the modernization process of an Industry 3.0 automated cell into a fully autonomous cell of Industry 4.0. The objective is to elucidate the difficulties found in this transition process and the possible ways to overcome the challenges, focusing on the management perspective.Design/methodology/approach - For this, the needed steps for the technology transition were defined and the main I4.0 enabling technologies were applied, such as the application of machine learning algorithms to control quality parameters in milling.Findings - The main challenges found were related to the obsolescence of the equipment present in the cell, challenges in data integration and communication protocols, in addition to the training of people who work actively in the project team. The difficulties faced were discussed based on similar studies in the literature and possible solutions for each challenge.Originality/value - This understanding of possible barriers in the modernization process, and the step-by-step defined for this transition, can be important references for professionals working in manufacturing industries and researchers who aim to deepen their studies in this important and disruptive stage of world industrialization.