Nature in the ancient universe is manifested in the philosophers through various thoughts of the epoch, among them, through a particular hermeneutic of the homo mensura. From a reminiscent thinking about nature in the Hellenic world, the origins and implications of the interpretative approach of the homo mensura are analyzed, whose course will lead in posterity to an instrumental vision of nature that conceals its being. In this context, it will be shown how an openness to a dimension of the immeasurable in nature enables to understand it more deeply, beyond the sufficient reasons that are available for measuring and interpreting it in this way.