Ordinary and partial differential equations with operators containing the p-Laplace operator, the so called phi-Laplace operator, operators with variable exponents and the double phase operators have been studied thoroughly for at least the last 20 years and the amount of papers dealing with these subjects is huge. In this paper we deal with the problem of the existence of periodic solutions to some system of ODE's involving a fairly general operator generalizing in this form corresponding results for the areas of research just mentioned. In our results neither the function generating the differential operator nor the right hand side function in the boundary value problem considered are necessarily equal to the gradient of a function. Our main result is a here is a continuation theorem based on the Leray-Schauder degree theory which allows us to obtain the existence of solutions for the boundary value problem considered. (c) 2024 Elsevier Inc. All rights reserved.