It is proposed that thanks to its profound philosophical roots, the science of semiotics could be employed as a tool, heuristic in nature, in philosophy of science. Nevertheless, it is remarked that this possibility has been only slightly explored within relevant academic spheres, at least from a fully conscious and explicit intellectual perspective. This is a pity, since studies with clear and explicit semiotic foundations, within properly subjects on philosophy of science are scarce, while clearly and explicitly semiotic founded studies, tough non-explicit and perhaps even unconscious for their authors, permeate the fundamental intellectual discussion on scientific epistemology, to the point that it seems possible to state that some of them are part of the classical references for the scholars on the matter, without being recognized as such. Both types of work examples are referenced and briefly discussed.