Purpose: This work aims to inform about the role of Acinetobacter spp. in ocular infections highlighting the microbial multi-resistance, based on the scientific evidence of a decade. Methods: A bibliographic review was carried out based on different electronic databases such as: Pubmed, Scopus and Web of Sciences with emphasis on ocular pathologies caused by bacteria of the Acinetobacter genus, their treatment and antibiotic resistance. Results: 24 articles from indexed journals were included in the databases from January 2012 to January 2021 that met the inclusion and exclusion criteria. Conclusion: It is advisable to detect the etiological agent and perform antimicrobial susceptibility tests, since they are the basis for an effective treatment, also helping to reduce the future appearance of multi-resistant strains. According to the information collected on pharmacological therapy, the use of fluoroquinolones has good activity against Acinetobacter, proving to be the drug that presented the highest susceptibility efficacy against this pathogen. Despite the good response to the management of ocular infections, it is necessary to carry out more controlled and randomized studies in this search for new antibacterial therapies.