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| DOI | 10.1016/J.NEUROBIOLAGING.2023.09.016 | ||||
| Año | 2023 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
The underlying neural mechanisms underpinning the association between age-related hearing loss (ARHL) and dementia remain unclear. A limitation has been the lack of functional neuroimaging studies in ARHL cohorts to help clarify this relationship. In the present study, we investigated the neural correlates of feature binding in visual working memory with ARHL (controls = 14, mild HL = 21, and moderate or greater HL = 23). Participants completed a visual change detection task assessing feature binding while their neural activity was synchronously recorded via high-density electroencephalography. There was no difference in accuracy scores for ARHL groups compared to controls. There was increased electrophysiological activity in those with ARHL, particularly in components indexing the earlier stages of visual cognitive processing. This activity was more pronounced with more severe ARHL and was associated with maintained feature binding. Source space (sLORETA) analyses indicated greater activity in networks modulated by frontoparietal and temporal regions. Our results demonstrate there may be increased involvement of neurocognitive control networks to maintain lower-order neurocognitive processing disrupted by ARHL.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Loughrey, David G. | - |
Trinity College Dublin - Irlanda
University of California, San Francisco - Estados Unidos Univ Dublin - Irlanda UNIV CALIF SAN FRANCISCO - Estados Unidos Trinity Coll Dublin - Irlanda |
| 2 | Jordan, Catherine | - |
Trinity College Dublin - Irlanda
University of California, San Francisco - Estados Unidos Univ Dublin - Irlanda UNIV CALIF SAN FRANCISCO - Estados Unidos Trinity Coll Dublin - Irlanda |
| 3 | LEGAZ, AGUSTINA | Mujer |
Trinity College Dublin - Irlanda
University of California, San Francisco - Estados Unidos Universidad de San Andrés - Argentina Universidad Adolfo Ibáñez - Chile Univ Dublin - Irlanda UNIV CALIF SAN FRANCISCO - Estados Unidos Univ San Andres - Argentina Trinity Coll Dublin - Irlanda |
| 4 | Rodriguez, M. | Hombre |
University of Strathclyde - Reino Unido
Univ Strathclyde - Reino Unido |
| 5 | Lawlor, Brian A. | - |
Trinity College Dublin - Irlanda
University of California, San Francisco - Estados Unidos Univ Dublin - Irlanda UNIV CALIF SAN FRANCISCO - Estados Unidos Trinity Coll Dublin - Irlanda |
| 6 | Reilly, Richard B. | - |
Trinity College Dublin - Irlanda
Univ Dublin - Irlanda Trinity Coll Dublin - Irlanda |
| Agradecimiento |
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| David Loughrey is an Atlantic Fellow for Equity in Brain Health at the Global Brain Health Institute (GBHI) and is supported with funding from GBHI, Alzheimer’s Association, and Alzheimer’s Society (GBHI ALZ UK-19-591089). |
| David Loughrey is an Atlantic Fellow for Equity in Brain Health at the Global Brain Health Institute (GBHI) and is supported with funding from GBHI, Alzheimer's Association, and Alzheimer's Society (GBHI ALZ UK -19-591089) . |