This study uses data from two waves of the Encuesta Longitudinal de Empresas (ELE) to examine the relationship between information and communication technologies (ICT) use and product innovation in Chilean firms. Our findings sustain the hypothesis that ICT act as enablers of innovation. However, the impacts of ICT on product innovation depend on the type of application considered. In particular, we find positive and significant association between production-integrating ICT, i.e. administrative and industry-specific software, and product innovation, while this is not the case for market-oriented ICT such as e-commerce or client relationship manager software. Finally, the results show that not every ICT combination is beneficial for innovation: firms that show a basic use of ICT are not associated with a better likelihood of introducing innovation, while firms with an advanced use of ICT are those with the more likelihood of innovating.