To compare clinical outcomes between an enhanced and a conventional monofocal intraocular lens (IOL) after cataract surgery.Setting:Ophthalmology Unit, Hospital del Salvador, University of Chile (tertiary care hospital).Design:Double-masked, prospective randomized controlled trial.Methods:66 healthy adults with corneal astigmatism less than 1.50 diopters and axial length between 21 and 27 mm were randomly allocated (1:1) for bilateral phacoemulsification with either an enhanced monofocal IOL (ICB00) or a conventional aspheric monofocal IOL (ZCB00) implant. The refractive target was emmetropia in both eyes. Visual acuities, defocus curves, Catquest-9SF, and quality of vision (QoV) were measured 3 months postoperatively.Results:Binocular uncorrected intermediate visual acuity was improved in patients implanted with the enhanced monofocal lens (0.37 ± 0.12) compared with the conventional monofocal (0.45 ± 0.10) (P <.01). There were no significant differences in corrected distance visual acuity (CDVA), Catquest-9SF, or QoV scores.Conclusions:The enhanced monofocal IOL provided 1 additional line of intermediate visual acuity after cataract surgery. There was no significant change in either CDVA or QoV.