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| Indexado |
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| DOI | 10.7717/PEERJ-CS.1490 | ||||
| Año | 2023 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Alzheimer's disease (AD) is a progressive type of dementia characterized by loss of memory and other cognitive abilities, including speech. Since AD is a progressive disease, detection in the early stages is essential for the appropriate care of the patient throughout its development, going from asymptomatic to a stage known as mild cognitive impairment (MCI), and then progressing to dementia and severe dementia; is worth mentioning that everyone suffers from cognitive impairment to some degree as we age, but the relevant task here is to identify which people are most likely to develop AD. Along with cognitive tests, evaluation of the brain morphology is the primary tool for AD diagnosis, where atrophy and loss of volume of the frontotemporal lobe are common features in patients who suffer from the disease. Regarding medical imaging techniques, magnetic resonance imaging (MRI) scans are one of the methods used by specialists to assess brain morphology. Recently, with the rise of deep learning (DL) and its successful implementation in medical imaging applications, it is of growing interest in the research community to develop computer-aided diagnosis systems that can help physicians to detect this disease, especially in the early stages where macroscopic changes are not so easily identified. This article presents a DL-based approach to classifying MRI scans in the different stages of AD, using a curated set of images from Alzheimer's Disease Neuroimaging Initiative and Open Access Series of Imaging Studies databases. Our methodology involves image pre-processing using FreeSurfer, spatial data-augmentation operations, such as rotation, flip, and random zoom during training, and state-ofthe-art 3D convolutional neural networks such as EfficientNet, DenseNet, and a custom siamese network, as well as the relatively new approach of vision transformer architecture. With this approach, the best detection percentage among all four architectures was around 89% for AD vs. Control, 80% for Late MCI vs. Control, 66% for MCI vs. Control, and 67% for Early MCI vs. Control.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Mora-Rubio, Alejandro | - |
Univ Autonoma Manizales - Colombia
Universidad Autónoma de Manizales - Colombia |
| 2 | Bravo-Ortiz, Mario Alejandro | - |
Univ Autonoma Manizales - Colombia
Universidad Autónoma de Manizales - Colombia |
| 3 | Arredondo, Sebastian Quinones | - |
Univ Autonoma Manizales - Colombia
Universidad Autónoma de Manizales - Colombia |
| 4 | Torres, Jose Manuel Saborit | - |
Fdn Fomento Invest Sanitario & Biomed Comun Valenc - España
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana - España |
| 5 | RUZ-HEREDIA, GONZALO ANDRES | Hombre |
Centro de Ecología Aplicada y Sustentabilidad - Chile
Data Observ Fdn - Chile Universidad Adolfo Ibáñez - Chile Centro de Ecología Aplicada y Sustentabilidad (CAPES) - Chile Data Observatory Foundation - Chile Universidad Asdolfo Ibáñez - Chile |
| 6 | Tabares-Soto, Reinel | - |
Univ Autonoma Manizales - Colombia
Universidad Adolfo Ibáñez - Chile Univ Caldas - Colombia Universidad Autónoma de Manizales - Colombia Universidad Asdolfo Ibáñez - Chile Universidad de Caldas - Colombia |
| Fuente |
|---|
| National Institutes of Health |
| Canadian Institutes of Health Research |
| National Institute on Aging |
| U.S. Department of Defense |
| University of Southern California |
| National Institute of Biomedical Imaging and Bioengineering |
| ANID PIA/BASAL |
| DOD ADNI |
| Alzheimer's Disease Neuroimaging Initiative |
| DOD ADNI (Department of Defense) |
| Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health) |
| Universidad Autónoma de Manizales |
| ANID/PIA/ANILLOS |
| Oportunidades de Mercado para las Empresas de Tecnología |
| Northern California Institute for Research and Education |
| Agradecimiento |
|---|
| This work was supported by the Universidad Autonoma de Manizales as part of the project "Deteccion de COVID-19 en imagenes de rayos X usando redes neuronales convolucionales" with code 699-106, and also to the projects "CH-T1246: Oportunidades de Mercado para las Empresas de Tecnologia-Compras Publicas de Algoritmos Responsables, Eticos y Transparentes", ANID PIA/BASAL FB0002, and ANID/PIA/ANILLOS ACT210096. Data collection and sharing for this project was funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904) and DOD ADNI (Department of Defense award number W81XWH-12-2-0012) . ADNI is funded by the National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the following: AbbVie, Alzheimer's Association; Alzheimer's Drug Discovery Foundation; Araclon Biotech; BioClinica, Inc.; Biogen; Bristol-Myers Squibb Company; CereSpir, Inc.; Cogstate; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli Lilly and Company; EuroImmun; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; Fujirebio; GE Healthcare; IXICO Ltd.; Janssen Alzheimer Immunotherapy Research & amp; Development, LLC.; Johnson & amp; Johnson Pharmaceutical Research & amp; Development LLC.; Lumosity; Lundbeck; Merck & amp; Co., Inc.; Meso Scale Diagnostics, LLC.; NeuroRx Research; Neurotrack Technologies; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Piramal Imaging; Servier; Takeda Pharmaceutical Company; and Transition Therapeutics. The Canadian Institutes of Health Research is providing funds to support ADNI clinical sites in Canada. Private sector contributions are facilitated by the Foundation for the National Institutes of Health ( www.fnih.org) . The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer's Therapeutic Research Institute at the University of Southern California. There was no additional external funding received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| This work was supported by the Universidad Autonoma de Manizales as part of the project “Detección de COVID-19 en imágenes de rayos X usando redes neuronales convolucionales” with code 699-106, and also to the projects “CH-T1246: Oportunidades de Mercado para las Empresas de Tecnología—Compras Públicas de Algoritmos Responsables, Éticos y Transparentes”, ANID PIA/BASAL FB0002, and ANID/PIA/ ANILLOS ACT210096. Data collection and sharing for this project was funded by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904) and DOD ADNI (Department of Defense award number W81XWH-12-2-0012). ADNI is funded by the National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the following: AbbVie, Alzheimer’s Association; Alzheimer’s Drug Discovery Foundation; Araclon Biotech; BioClinica, Inc.; Biogen; Bristol-Myers Squibb Company; CereSpir, Inc.; Cogstate; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli Lilly and Company; EuroImmun; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; Fujirebio; GE Healthcare; IXICO Ltd.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Lumosity; Lundbeck; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; NeuroRx Research; Neurotrack Technologies; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Piramal Imaging; Servier; Takeda Pharmaceutical Company; and Transition Therapeutics. The Canadian Institutes of Health Research is providing funds to support ADNI clinical sites in Canada. Private sector contributions are facilitated by the Foundation for the National Institutes of Health (www.fnih.org). The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer’s Therapeutic Research Institute at the University of Southern California. There was no additional external funding received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |