Southern South America is the only large landmass that extends through the core of the Southern Westerly Winds (SWW), controlling hydrological and ecosystem variability in the region. In fact, the vegetation along the west coast changes from Temperate and Valdivian Rain Forest to the North Patagonian Evergreen Forest (ca. 42°S) due to the latitudinal influence of the SWW. Climate is an important driver of organic matter accumulation in lakes, hence changes in vegetation would be recorded in lacustrine sedimentary archives. This study evaluated leaf waxes contained in lake surface sediments as indicators of climate change along the west coast of southern South America, providing a biogeochemical dataset for ongoing and future (paleo)climate and environmental research. The fatty acid and n-alkane sediment leaf wax datasets are compared with latitudinal, orographic, and climatic (Mean Annual air Temperature [MAT] & Precipitation [MAP]) trends extracted from a monthly gridded reanalysis product of the Climate Forecast System Reanalysis. Fatty acids are more abundant than n-alkanes, with high abundances characterizing the transition between seasonal and year-round precipitation along the coast (ca. 42°S). The abundance of both leaf wax groups increases with MAP, suggesting precipitation as the main control on sedimentary leaf wax delivery to the lake sediments in the study area. The Carbon Preference Index (CPI) of the two groups show opposite trends, but both highlight the climate transition at ca. 42°S, and have a linear relationship with MAP. The opposite significant trends between n-alkane CPI and fatty acid CPI with MAP are interpreted as higher n-alkane production at much higher precipitation because leaf wax fatty acids are the precursors of n-alkanes. Hence, past periods during which these leaf waxes show opposite trends in CPI might be interpreted as a precipitation change, especially if additional information such as pollen, diatoms, chironomids and stable isotopes is available.