This chapter describes the opportunities related to the application of additive manufacturing to the design and manufacturing of non-standard load-bearing structures, focusing on space frames. With 3D Printing, space frames design is not limited by standard components and standard fabrication methods, enabling optimized frames in which the frame topology and nodal joints are specialized for their specific stresses within the structure. Digital design approaches and workflows, including the overall form generation, element definition, and topology optimization are presented in detail. As a case study, the chapter presents an in-depth analysis of the design and manufacturing workflows for AirMesh, a stainless steel pavilion developed by AirLab.